Aim: To investigate the role of glutathione metabolism in pancreatic CSCs. Methods: Primary pancreatic cancer cells of patient-derived xenografts (PDXs) were cultured in adherent or CSC-enriching sphere conditions to determine the role of glutathione metabolism in stemness. Real-time polymerase chain ...
Genetic defects in glutathione metabolism are rare and inherited in an autosomal recessive fashion. A total genetic deficiency of the enzymes of glutathione biosynthesis in mammals is unknown; most inborn errors are associated with frameshift and point mutations, splicing variations, and unstable enzymes...
网络谷胱甘肽代谢 网络释义 1. 谷胱甘肽代谢 谷胱甘肽代谢(glutathione metabolism) 3: glrx2 gsr gsta1固醇代谢 (sterol metabolism) 1: ebpl 寡糖代谢 (oligosaccharide meta... www.eiaab.cn|基于 1 个网页
Aim: To investigate the role of glutathione metabolism in pancreatic CSCs. Methods: Primary pancreatic cancer cells of patient-derived xenografts (PDXs) were cultured in adherent or CSC-enriching sphere conditions to determine the role of glutathione metabolism in stemness. Real-time polymerase chain ...
22 proteins that demonstrated significantly different expression levels were identified by mass spectrometry coupled with genome-wide analysis ofE. coli. Most of the proteins were involved in central metabolism and amino acid metabolic processes. Pyruvate kinase (encoding bypykF) catalyzes phosphoenolpyruvi...
ABCC1 overexpression induces resistance to BCL-2 inhibitors by reducing intracellular drug levels, and high ABCC1 levels predicts poor response to Venetoclax therapy in patients. Consistent with ABCC1-specific export of glutathionylated substrates, inhibition of glutathione metabolism increases the potency...
[1] Glutathione metabolism 来自 Elsevier 喜欢 0 阅读量: 232 作者: A Meister 摘要: Glutathione (GSH), which is an α-amino acid as well as a tripeptide, evolved as a molecule that protects cells against oxidation. It has a number of important functions in metabolism, catalysis, and ...
[1]. It is therefore rather surprising that many fundamental mechanistic questions still remain to be solved in order to precisely understand the role ofglutathione metabolismat the cellular and organismic level. This review is a (doomed) attempt to summarize the knowledge on glutathione-dependent ...
Herbicide Metabolism: Crop Selectivity, Bioactivation, Weed Resistance, and Regulation glutathione S-transferaseherbicide safenernatural phytotoxinoxylipinSeveral grass and broadleaf weed species around the world have evolved multiple-herbicide ... Nandula, Vijay K.Riechers, Dean E.Ferhatoglu, YurdagulBarr...
Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. J Appl Toxicol 1999;19(3):193-8.Mizutani T, Murakami M, Shirai M, Tanaka M, Nakanishi K. Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. J Appl Toxicol. 1999; 19 :193–198....