Mechanism of action Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It also plays a role in the hepatic biotransformation and detoxification process; it acts as a hydrophilic molecule that is added to other lipophilic toxins or wastes ...
Proposed mechanisms of action include: (a) direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme; (b) mediating the switch mechanism from eumelanin to phaeomelanin production; (c) quenching of free radicals and peroxides that contribute to ...
Mechanism of Action GSH is an extremely important cell protectant. It directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules. GSH is a primary protectant of skin, lens, cornea, and retina against radiation damage and...
oxidative cleavage of the P–S bond could be achieved by oxidases like laccases. These enzymes could be used in association with other OP-degrading enzymes for skin decontamination or in topical skin protection formulations. Though no work has been performed on the combined action of oxidases and...
The chemical process behind how DMSA works to chelate heavy metals from the body is somewhat technical and beyond the scope of this article. The basic mechanism is that DMSA has receptor sites that the heavy metals bind to. New research suggests the following action. Heavy metals reside inside...
suggesting a universal molecular regulatory circuit between IRE1α and the cellular ferroptotic machinery. Another FIN with a distinct mechanism of action in inducing ferroptosis, RSL311, had similar differential ferroptosis induction in wild-type and IRE1α-null MDA-MB-231 cells, suggesting that ...
phospholipid hydroperoxides has been studied., Results of these studies indicate that the alpha class GST fraction, which consists of three isoforms, has glutathione peroxidase activity toward phospholipid hydroperoxides residing in biological membranes, without the need of prior phospholipase C action. ...
In this context, it is necessary to clarify the mechanism of these enzymes in cell resistance and their true prognostic value [28, 29]. Knowledge of GSH expression and its enzymes in a wide range of biology processes is expanding. Advances in analytical techniques and protein localization will ...
with anti-nrf2 or anti-phospho-c-jun antibody. the results shown are representative of 4 experiments. expression of other phase ii enzymes we also assessed the expression of other detoxification enzymes that are known to be upregulated by a nrf2-dependent mechanism, including gsta, gatm, and ...
et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat. Chem. Biol. 12, 109–116 (2016). Article CAS Google Scholar Seashore-Ludlow, B. et al. Harnessing connectivity in a large-scale small-molecule sensitivity dataset. Cancer Discov. 5, 1210–...