Wilk. Localization of immunoreactive glutamyl aminopeptidase in rat brain. II. Distribution and correlation with angiotensin II. Brain Res. 606: 295-303, 1993.Healy, D.P., Wilk, S., 1993. Localization of immuno
The article discusses the potential of pyroglutamyl aminopeptidase 1 (PGP-1) as a novel target for diagnosing and treating inflammation. PGP-1 is a cysteine peptidase found in various organisms and tissues, with roles in peptide absorption, catabolism, and disease regulation. Studies have shown an...
Contribution of muscle aminopeptidases to flavor development in dry-cured ham 10.1016/S0963-9969(00)00032-6 Virgili et al., 2007 R. Virgili, G. Saccani, L. Gabba, E. Tanzi, C. Soresi Bordini Changes of free amino acids and biogenic amines during extended ageing of Italian dry-cured ha...
Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M: Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Ch...
oxydation step should also be inserted). If desired, these polymers can be decomposed into the monomeric substances of the general formula (I) using the method of process variant (v). The decomposition can be performed by enzymatic hydrolysis using e.g. carboxypeptides or leucinaminopeptidase. ...
It is therefore suggested that this TRH-like CNS activity may be due to inhibition of endogenous TRH degradation.; Potential transition state analog inhibitors of TRH degradation by pyroglutamyl aminopeptidase were also proposed. The ability of these potential inhibitors to assume conformations similar ...
Therefore, the dependence of Glu-Cys-Gly-like tripeptides on Dug1p for growth indicates that an aminopeptidase-like activity must exist that acts on tripeptides releasing Cys-Gly, which is then acted on by Dug1p. It would be interesting to identify if there might be a specific aminopeptidase...
Since pGlu-Aβ peptides appear highly abundant, and since pGlu-Aβ formation prevents intracellular aminopeptidase-mediated disposal of such improperly generated peptides [30], [35], inhibition of brain QC and EC activity could prove a valuable tool to combat the onset and progression of ...