Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with different morphological and molecular subtypes and responses to therapy, and breast cancer cells are known to rewire ...
The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate, satisfying the ‘glutamine addiction’ of cancer cells. They are the targets of anti-cancer drugs; however, their mechanisms of activation and catalytic activity have been unclear. Here we demonstrate that the ...
Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by theELAVL1gene) influences mRNA stability and alternative splicing. Overexpression ofELAVL1is common in several cancers, including breast cancer...
The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated during tumorigenesis and is being evaluated as a target for cancer therapy. GLS catalyzes the hydrolysis of glutamine to glutamate, which then supplies diverse metabolic pathways with carbon and/or nitrogen. Here, we report that SI...
Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) influences mRNA stability and alternative splicing. Overexpression of ELAVL1 is
Keywords: glutaminase, acetylation, HDAC4, TRIM21, non-small cell lung cancer IntroductionReprogramming of cellular metabolism is a hall marker of tumorigenesis. Transformed cells often converts the majority of their glucose to lactate regardless of O2 availability (Warburg effect), as well as increas...
Twitter Google Share on Facebook glutaminase Medical Encyclopedia Wikipedia (ɡluːˈtæmɪˌneɪz; ˈɡluːtəmɪˌneɪz) n (Biochemistry)biocheman enzyme used to treat cancer Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers...
The aim of this study was to analyze the significance of glucose metabolism-related enzymes in the proliferation of gastric cancer under hypoxia. Four hypoxia-resistant gastric cancer cell lines and 4 parent cell lines were used. RT-PCR was used to evaluate the mRNA expression levels of the fol...
Taylor & Francis Online :: Analysis of glutamine dependency in non-small cell lung cancer - Cancer Biology & Therapy - Volume 13, Issue 12 One of the hallmarks of cancer is metabolic deregulation. Many tumors display increased glucose uptake and breakdown through the process of aerobic glycoly....
Analysis of glutamine dependency in non-small cell lung cancer One of the hallmarks of cancer is metabolic deregulation. Many tumors display increased glucose uptake and breakdown through the process of aerobic glycoly... A Pieter,J Van,den,... - 《Cancer Biology & Therapy》 被引量: 95发表...