(1995). Glutamate gamma-semialdehyde as a natural transition state analogue inhibitor of Escherichia coli glucosamine- 6-phosphate synthase. Biochemistry 34, 11515-11520. doi: 10.1021/bi00 036a026Bearne, S.L. and R. Wolfenden, Glutamate gamma-semialdehyde as a natural transition state analogue ...
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for their role in cancer and inherited metab...