Glutamate Dehydrogenase 1 (GDH), encoded by the Glud1 gene in rodents, is a mitochondrial enzyme critical for maintaining glutamate homeostasis at the tripartite synapse. Our previous studies indicate that the hippocampus may be particularly vulnerable to GDH deficiency in CNS. Here, we first asked...
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Glutamate dehydrogenase 1 (EC=1.4.1.3) is an enzyme localized in mitochondrial matrix which plays a key role in nitrogen and glutamate metabolism. 应用类型 Immunolocalization (IL), Western blot (WB) 免疫原 KLH-conjugated synthetic peptide derived from a full-length cDNA sequence of Lupinus luteus...
GDH1 | glutamate dehydrogenase 1, product information background Glutamate dehydrogenase 1 (EC=1.4.1.3) is an enzyme localized in mitochondrial matrixwhich plays a key role in nitrogen and glutamate metab
公司:武汉菲越生物科技有限公司 联系人:李洋 产品属性 产品说明 产品名称:谷氨酸脱氢酶(GLUD1)重组蛋白 别称:GDH; Glutamate dehydrogenase 1, mitochondrial 物种:Bovine 应用:Western Blot; ELISA; Standard Uniprot ID: 性状:冻干粉 预测分子量: 含量:> 97% by SDS-PAGE and HPLC analyses ...
Glutamatedehydrogenase(GLDH)isamitochondrialenzymepresent inalltissues.Thephysiological unctiono GLDHistheoxidative deaminationo glutamate.Measurableincreasesinserumlevelsare indicativeo hepatocellularnecrosis. ElevatedserumGLDHlevelsindicateliverdamageandGLDHplaysan importantroleinthedi erentialdiagnosiso liverdisease,especi...
Congenital hyperinsulinism/hyperammonemia (HI/HA) syndrome is caused by an activation mutation of glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme responsible for the reversible interconversion between glutamate and -ketoglutarate. The syndrome presents clinically with hyperammonemia, significant episod...
FunctionGlutamate dehydrogenase is used to catalyze the conversion of isocitrate into α-ketoglutarate and carbon dioxide. SynonymsNAD(P)+, GDH1, L-GDH, GDH, Glutamate dehydrogenase 1, mitochondrial, L-Glutamate:NAD(P)+ oxidoreductase Molecular Weight~350,000 ...
A new class of glutamate dehydrogenase (GDH) is reported. The GDH of Streptomyces clavuligerus was purified to homogeneity and characterized. It has a native molecular mass of 1,100 kDa and exists as an α6 oligomeric structure composed of 183-kDa subunits. GDH, which requires AMP as an ...
How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated in human cancers. GDH1 is important for redox homeostasis in cancer cells by controlling the intracellula...