Glutamate cysteine ligase (GCL), which synthesizes γ-glutamyl-cysteine (γ-GC), is the rate-limiting enzyme in GSH biosynthesis. γ-GC may be produced by the catalytic subunit GCLC or by the holoenzyme (GCLholo), which comprises GCLC and the modifier subunit GCLM. The Gclm (–/–) ...
Glutamate Cysteine Ligase, Catalytic (GCLC) Recombinant, Human 供应商 USBiological 产品货号 154782 产品报价 ￥1/10ug ￥1/50ug 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868
中文名称: 谷氨酸半胱氨酸连接酶催化亚基(GCLC)重组蛋白 中文同义词: 谷氨酸半胱氨酸连接酶催化亚基(GCLC)重组蛋白 英文名称: Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC) 英文同义词: Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC) CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告...
Ferritin heavy polypeptide 1 (FTH1), glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase modifier subunit (GCLM), glutathione reductase (GSR), and thioredoxin reductase 1 (TXNRD1) are also target genes of Nrf2[68]. Kato et al.[68]found that the mRNA expression level...
1.To characterize the promoter of rat γ-glutamyl cysteine synthetase(γ-GCS),either or both of the two AHR/ARNT elements upstream of glutamate-cysteine ligase catalytic subunit(GCLC) were deleted to construct luciferase reporter vectors based on the rat GCLC 1.研究谷氨酰半胱氨酸合成酶催化亚单...
苏州科铭生物技术有限公司inbio 订购电话:***-***165邮箱:comin@cominbio γ-谷氨酰半胱氨酸连接酶(glutamatecysteineligase,GCL)试剂盒说明书(50T) 一、测定意义 GCL是由催化亚基GCLC和调节亚基GCLM组成异二聚体。GCL是GSH合成的限速酶,GSH对GCL有反馈抑制作用。GCL作为GSH合成的限速酶,其本身或者其亚单位GCL...
The rate-limiting step is the binding of glutamate and cysteine, which is catalyzed by the enzyme glutamate-cysteine ligase (GCL). This enzyme is composed of two subunits: a large catalytic subunit (GCLc) and a smaller modifying subunit (GCLm), originating from different genes. Control of ...
1.2Glutamate cysteine ligase HumanGCL, also known as γ-glutamylcysteine synthetase (GCS), is aholoenzymecomprising a ∼73 kDacatalytic subunit(GCLC), 637 amino acids in length and a ∼31 kDa modifier (GCLM) subunit, 274 amino acids in length[13]. ...
Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytesVitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-...
GCLC, catalytic subunit of glutamate-cysteine ligase; GCLM, modulatory subunit ofglutamate-cysteine ligase; ARE, antioxidant by GSH15,16 and by the avail- ability of its precursor,L-cysteine.1,5,7 Besides the GCL genes, AREs have been iden- tified in the 5-flanking region Animals...