Insulin resistance is identified as a major characteristic in the pathogenesis of type 2 diabetes. Thus, our aim was to evaluate the association of UGE with serum insulin levels and insulin resistance in subjects with glucose abnormalities, including prediabetes and newly diagnosed diabetes (NDD). ...
It is generally believed that glucose production (GP) cannot be adequately suppressed in insulin-treated diabetes because the portal-peripheral insulin gradient is absent. To determine whether suppression of GP in diabetes depends on portal insulin levels, we performed 3-h glucose and specific activity...
Aims Hypoglycaemia remains a major barrier preventing optimal glycaemic control in Type 1 diabetes due to the limitations of conventional insulin preparations. We investigated whether basal-bolus therapy with insulin detemir (detemir), a new soluble basal insulin analogue, was more effective in reduc...
(d) Fasted mice received sham or vagal stimulation (VS), and serum insulin levels were analyzed at the indicated time points. *p < 0.05 vs LPS (n = 4/group; Two-way ANOVA). (e,f) Fasted mice underwent sham or surgical pancreatectomy (PX) 1 day before LPS, underwent sham...
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program ArticleOpen access28 July 2022 Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association ofGIGYF1loss of function with type...
individuals with fastingplasma glucoseconcentration between 110 and 125mg/dl[9]. IFG has been adopted by NCEP ATP III guidelines as one of the criterion for identifying subjects with metabolic syndrome. However, insulin resistance is also seen in many individuals having normal fastingglucose levels[...
Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects. We have investigated the relationships between plasma interleukin-6 (IL-6) levels and insulin sensitivity and insulin secretion in a cohort of Italian-Cauc... F Andre...
Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells Gohring I, Sharoyko VV, Malmgren S, Andersson LE, Spegel P, Nicholls DG and Mulder H: Chronic high glucose and pyruvate levels differentially...
whether these alterations are triggered rather by low circulating insulin levels or by hyperglycemia [220,231]. In the context of microvascular complications, however, decreased GLUT1 levels in the retina have been described to be beneficial in the prevention of retinopathy as a diabetic late complic...
Plasma glucose and insulin levels were determined under basal and clamps conditions by the glucose oxidase method (Glu, Roche Diagnostics GmbH, Rotkreuz, Switzerland) and enzyme immunoassay (SPI bio, Montigny Le Bretonneux, France), respectively. Assay of de-novo lipogenic enzyme activities Fatty ...