Introduction:Energy Metabolism in the BrainThe Cerebral Glucose-Fatty Acid Cycle: Evolutionary roots, regulation, and (patho)physiological importance Expression, Regulation and Functional Role of Glucose Transporters (GLUTs) in BrainInsulin-Like Growth Factor 1 Promotes Neuronal Glucose Utilization During ...
Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies.doi:10.1203/00006450-197108000-00008Chase, H PeterKumar, VijayRodgerson, Denis OCheung, Geoffrey P
“Such neuroimaging methods provide unprecedented information on brain metabolism,” says Chaumeil. “The promise of metabolic imaging to inform fundamental biology and improve clinical care is immense; a lot remains to be explored.” The imaging results helped prove that neurons metabolize ...
In addition to food intake, vagal afferents also mediate the ability of intestinal nutrients to regulate hepatic glucose production. Infusion of lipids and carbohydrates into the small intestine initiates a gut–brain–liver axis that is dependent on vagal signaling to lower hepatic glucose production ...
This chapter details the physiological relevance of glucose metabolism in brain functioning and describes relevant glucose-mediated pathways that are altered during aging and age-related NDDs, summarizing numerous mechanisms modified by deregulated glucose levels, namely, the link to diabetes. Cognitive ...
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adipos...
loping Rabbit Brain Interrelationships of Glucose, Glutamate and Aspartate Metabolism in Developing Rabbit BrainInterrelationships of Glucose, Glutamate and Aspartate Metabolism in Developing Rabbit BrainStudies in this laboratory have demonstrated that glutamate and aspartate have different metabolic effects than...
Opioid withdrawal produced both similar and unique alterations in regional brain metabolism in male and female animals. Specifically, similar changes were observed in the thalamus, insular cortex, and the periaqueductal gray. However, compared with males, female exhibited increased metabolism in the pre...
Anoxic survival with glucose Eflect of Glucose on Brain Energy Metabolism during Anoxia T h e life-saving effect of glucose in anoxic mice does not appear to be related to its osmotic activity, inas- much as mannitol in equal dosage was without effect. I n a n attempt to understand the ...
Marcelin, G. et al. Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism. Mol. Metab. 3, 19–28 (2014). CAS PubMed Google Scholar Liu, S. et al. A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibrob...