The study sought to compare the effectiveness of glucose-like peptide-1 receptor agonists (GLP-1RAs) with dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, or sodium-glucose cotransporter-2 (SGLT-2) inhibitors in reducing decompensation events, among patients with cirrhosis and type 2 ...
muciniphila and metabolic phenotypes: OGTT AUC (oral glucose tolerance test area under the curve), iBAT temp (interscapular brown adipose tissue temperature), and GLP-1 (plasma glucagon-like peptide-1 concentration). f–h, mRNA expression of M1 and M2 macrophage markers in iBAT, igWAT, and...
Non-peptidic glucose-like peptide-1 receptor agonists: aftermath of a serendipitous discovery. Acta Pharmacol. Sin. 31 (9), 1026-1030.Wang, M. W., Liu, Q. & Zhou, C. H. Non-peptidic glucose-like peptide-1 receptor agonists: aftermath of a serendipitous discovery. Acta Pharmacol. Sin. ...
This study assessed whether treatment with the glucagon-like peptide receptor agonist (GLP-1 RA) exenatide (EXE) could prevent GC-induced glucose intolerance. A randomized, placebo-controlled, double-blind, crossover study in eight healthy men (age: 23.5 [20.0–28.3] years; BMI: 26.4 [24.3–...
Toll-like receptor 4GlucoseGlucagon-like peptide-1Tumor necrosis factor alphaInterleukin-6Lipopolysaccharide (LPS), a natural toll-like receptor 4 (TLR4) ligand, can induce the secretion of glucagon-like peptide-1 (GLP-1) in both animal models and humans consistent with the notion that TLR4 may...
Glucagon‑like peptide‑1 (GLP‑1) is a gut incretin hormone that is considered to be a promising target for the treatment of patients with type 2 diabetes. However, the mechanisms underlying the protective effects of GLP‑1 on diabetic nephropathy are yet to be fully elucidated. Sirtui...
Fig. 1 Main physiological actions of the dual GIP and GLP-1 agonist tirzepatide. GIP—glucose-dependent insulinotropic polypeptide; GLP-1—glucagon-like peptide-1. Despite the similarities between the two incretins, it should be pinpointed that while GIP activity is mainly pancreatic, GLP-1 ac...
Glucagon-like peptide-1 (GLP-1) is a 30 amino acid incretin hormone produced by the intestinal enteroendocrine L-cells3. It shares several common biological functions on pancreatic β-cells with glucose, such as promoting insulin secretion and cell survival4. GLP-1 can potentiate both acute and...
AIMS: Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone released from the gut in response to nutrients. Besides its well-established direct effect on pancreatic beta cells, GLP-1 may also act by activating sensors in the hepatoportal area. We therefore studied the impact of putative...
Triggering glucagon like peptide 1 secretion; nonglucose carbohydrate and soluble fiber; metabolic syndrome, diabetes, obesity, promotion of satietyUS 20040087514 A1 Abstract Compositions comprising soluble fiber are effective in triggering the secretion of GLP-1. Compositions may be used in the ...