胰高糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种主要由肠道L细胞所产生的激素,属于肠促胰素(incretin)。 胰高糖素样肽-1受体激动剂(GLP-1RA)是近年来的新型降糖药,通过激活GLP-1受体,以葡萄糖浓度依赖的方式增强胰岛素分泌,抑制胰高糖素分泌,并能够延缓胃排空,通过中枢性的食欲抑制减少进食量,从而达到...
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a drug used to treat type 2 diabetes, have been shown to have neuroprotective effects. This systematic review and meta-analysis evaluated the effects and potential mechanisms of GLP-1 RAs in AD animal models. 26 studie...
The unique glycine residue at the DPP-IV cleavage site renders the protein unrecognizable by DPP-IV and prolongs the half-life of the peptide. Thus, the exendin-4 backbone has been utilized in the creation of longer-acting synthetic GLP-1R agonists.Figure adapted from Glotfelty et al. [5]....
Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet β cells, promotion of islet β cell proliferation and ...
GLP-1/Glucagon-Like Peptide, amide, human Basic information More.. Product Name: GLP-1/Glucagon-Like Peptide, amide, human Synonyms: GLP-1/Glucagon-Like Peptide, amide, human;HIS-ALA-GLU-GLY-THR-TYR-THR-SER-ASP-ILE-THR-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-...
If you know of a relevant reference for Glucagon-like peptide 1 (7-36) amide (human, rat),please let us know. 关键词: Glucagon-like peptide 1 (7-36) amide (human, rat), Glucagon-like peptide 1 (7-36) amide (human, rat) supplier, Potent, insulinotropic, peptide, GLP-1, Receptors...
胰高血糖素样肽-1(Glucagon-likepeptide-1,GLP-1)是一种内源性肠促胰岛素激素,由31个氨基酸残基组成,由胰高血糖素原基因转录、翻译及加工而成。GLP-1具有葡萄糖浓度依赖性降糖作用,其受体激动剂(GLP-1RA)能够模拟GLP-1的生理作用,是降糖和减重药物研发的热门靶点。
The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis,...
Navarroet al(1996)Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake.J.Neurochem.671982 PMID: 8863504 ...
CAS No.:89750-14-1;107444-51-9 Synonyms:GLP-1-(7-36) amide;Glucagon-like peptide I;胰高血糖素样肽7-36 Catalog No.:153P05 Brand:HongTide(上海鸿肽生物) Description:GLP-1是人体分泌的一种肠道激素,由胰高血糖素原(Proglucagon)分子经肠道蛋白水解酶作用而产生,因而称为胰高血糖素类多肽或胰高...