We thank M. Montminy, T. Sonntag and Y.-S. Yoon for kindly providing the CRTC2 antibody and control samples, and for their advice on the interpretation of the CRTC2 blots; H. S. Sui for generously providing the pATGL antibody; D. Vatner for his advice on these studies; and X. Ma...
Glucagon test for phaeochromocytoma Lancet (1966) LundquistG. The cellular origin of pancreatic glucagon McIntyreN. et al. New interpretation of oral glucose tolerance Lancet (1964) SamolsE. et al. Promotion of insulin secretion by glucagon Lancet (1965) SamolsE. Stimulation of glucagon sec...
or pancreatic amylase or lipase greater than the upper limit of normal (ULN) at screening, (b) past history of gastroparesis requiring treatment, (c) past history of surgery affecting the upper gastrointestinal tract likely to affect the interpretation of safety and tolerability data, (d) history...
hepatocytes were incubated for 20 min with 991 or with DMSO as vehicle control in the presence of the PDE4 inhibitor rolipram before stimulation with indicated concentrations of glucagon
For these analogues, the location of FL incorporation within the exendin-4 peptide also likely occurs in a region of the peptide that binds the receptor N terminus, impacting accurate interpretation of interactions between exendin-4 and the GLP-1R N terminus using the cross-linking method (...
Cigarette smoking is the leading preventable cause of premature death. Despite dedicated programmes, quit rates remain low due to barriers such as nicotine withdrawal syndrome or post-cessation weight gain. Glucagon-like peptide-1 (GLP-1) analogues reduc
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However, HOMA-β represents β-cell function in the fasting state, not in response to nutritional stimulation. Further, major factors related to nutrient consumption, gender and age were adjusted differently: i.e. gender was used for stratification, and age was used for statistical adjustment as ...
Interpretation of findings obtained by RNase protection or RT-PCR analysis is complicated by uncertainties concerning whether or not there is functional expression of ryanodine receptor protein. Therefore, we tested for expression of ryanodine receptor binding sites by fluorescence microscopy using the BODIP...
Analysis and interpretation of the perfusion experiments were accomplished in terms of the previously determined accessible cell spaces, and chromatographic analyses were done in order to examine the purity of the various glucagon preparations [3]. The results are expected to inform further about the ...