Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. Here we show that intracerebroventricular (i.c.v.) GLP-1 and [Ser(2)]exendin(1–9) (HSEGTFTSD
The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types within the human body. This receptor specifically interacts with GLP-1, a key hormone that pla...
Structure and sequence of human glucagon-like peptide-1 (GLP-1) (according to PDB ID: 6X18) and GLP-1–derived drugs: exenatide, lixisenatide, liraglutide, albiglutide, dulaglutide, and semaglutide. Exenatide is the identical synthetic version of exendin-4 consisting of 39-amino aci...
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that promotes healthy insulin signaling, regulates blood sugar levels, and suppresses appetite. Consequently, numerous GLP-1 receptor (GLP-1R) stimulating drugs have been developed and approved by the US Food and Drug Administration (FDA) ...
葡萄糖依赖性促胰岛素释放多肽受体(Glucose-dependent insulinotropic polypeptide receptor,GIPR)、胰高血糖素样肽-1受体(Glucagon-like peptide-1 receptor,GLP-1R)和胰高血糖素受体(Glucagon receptor,GCGR)是调节糖脂和氨基酸代谢的B1类...
糖尿病和肥胖症是当今全球性的公共卫生负担,靶向胰高血糖素样肽-1受体(Glucagon-like peptide-1 receptor, GLP-1R)的单靶点和多重激动剂以其显著的降糖及减重疗效一跃成为“明星”药物1。GLP-1R由内源性激素GLP-1(7-36)激活进而控制血糖水平。但它在体内被二肽基肽酶4(Dipeptidyl peptidase-4, DPP-4)迅速降...
在此,我们综述了GLP-1RA在神经、心血管和内分泌系统中的治疗作用和可能作用机制及其与代谢、肿瘤和其他疾病的相关性。 Keywords: GLP-1 receptor agonists, endocrine, cardiovascular, neurological, cancer 关键词:GLP-1受体激动剂,内分泌,心血管,神经,癌症 Introduction 引言 Glucagon like peptide-1 (GLP-1) is...
英文名称：Glucagon - like peptide - 1 (GLP - 1)(7 - 36), amide acetate；Human GLP - 1 (7 - 36), amide acetate 中文名称：胰高血糖素样肽 - 1 (7 - 36) 酰胺醋酸盐 氨基酸序列：His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - ...
Patients with type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and stroke are responsible for 75% of all death in patients with diabetes, who present a
关键词: Glucagon-like peptide 1 (7-36) amide (human, rat), Glucagon-like peptide 1 (7-36) amide (human, rat) supplier, Potent, insulinotropic, peptide, GLP-1, Receptors, Glucagon-Like, Peptide, 1, Glucagon-like, peptide1, (7-36), amide, (human, rat), GLP1(7-36), 2082, ...