DPP-4 has two domains and two subdomains: α/β hydrolase domain (Gln508-Pro766), β-propeller domain (Arg54-Asn497), receptor binding subdomain, and a core subdomain [15]. DPP-4 was first identified as CD26, and is a 110 kD protein that can be found on the cell surface as a ...
There has been no effective medication for AAA other than surgical intervention. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been shown to have a protective effect on cardiovascular disease. Whether DPP-4 inhibitors may be beneficial in the treatment of AAA is unclear. We investigated the ...
DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators; Gerstein HC; Yusuf S; Bosch J; Pogue J; Sheridan P; Dinccag N; Hanefeld M; Hoogwerf B; Laakso M; Mohan V; Shaw J; Zinman B; Holman RR - 《Lancet》 被引量: 6459发表: 2006年 Diabetes ...
Although several classes of pharmacotherapy are available for type 2 diabetes, glycaemic control is often hampered by medication-related adverse effects an... VR Aroda,R Ratner - 《Diabetes/metabolism Research & Reviews》 被引量: 236发表: 2011年 Filgotinib (GLPG0634/GS-6034), an oral JAK1...
“Amylin hasn’t announced any work on an oral version of Byetta,” she told me. That does not mean that the company is not working on it. It may be, since not everything the pharmaceutical companies are doing is public knowledge. But it certainly does look now like the biggest limitati...
Barriers to utilization may be the short duration studies, lack of familiarity of the medication, the route of administration (injection) and the variable outcomes on ovulation and hyperandrogenism. KEYWORDS: Exenatide glucagon-like peptide-1 receptor agonists liraglutide obesity polycystic ovary ...
Because most randomised trials evaluated one antihyperglycaemic medication versus placebo, a head-to-head comparative effectiveness analysis of the newer drug classes (SGLT2 inhibitors vs GLP-1 receptor agonists) or newer (SGLT2 inhibitors or GLP-1 receptor agonists) versus older (DPP-4 inhibitors ...
Dihydromyricetin as a novel anti-alcohol intoxication medication. J. Neurosci. 2012, 32, 390–401. [Google Scholar] [CrossRef] [Green Version] Blad, C.C.; Tang, C.; Offermanns, S. G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug. Discov. ...
Besides an established medication for hypercholesterolemia, bile acid binding resins (BABRs) present antidiabetic effects. Although the mechanisms underlying these effects are still enigmatic, glucagon-like peptide-1 (GLP-1) appears to b... M Kohkichi,W Mitsuhiro,S Taichi,... - 《Endocrinology》...