Alcohol dehydrogenase (ADH) activity in stellate cells and the influence of the ADH inhibitor 4-methylpyrazole (4MP) on the response of these cells to ethanol was assessed. Malondialdehyde levels were determined as an indicator of lipid peroxidation. The effect of the antioxidant vitamin E on the...
It was immediately transferred to an iced centrifuged tube con- taining the protease inhibitor PMSF (phenyl methyl sulfonyl fluoride, SIGMA St. Louis, Missouri), 4 L/mL of 200-mmol solution. Samples were then centrifuged at 3000 g for 30 min at 4°C. Plasma was collected and stored ...
As BAPN is a specific lysyl oxidase inhibitor, the residual amine oxidase activity evidenced in the presence of BAPN was subtracted from the activity observed in the absence of BAPN. Lysyl oxidase activity was reported as the fold change versus CTRL of the pooled supernatant and cell layer ...
5. 达格列净,卡格列净,恩格列净药物说明书 6. SGLT2 inhibitor or GLP-1 receptor agonist in type 2 diabetes? Lancet Diabetes Endocrinol, 2019. 7. 中国循环杂志 2020 年 3 月第 35 卷第 3 期(总第 261 期) 8. Christopher...
钠-葡萄糖协同转运蛋白2抑制剂(sodium-dependent glucose transporters 2 inhibitor,SGLT-2)是一种新型口服降糖药物,目前在国内上市的SGLT-2抑制剂包括达格列净、恩格列净、卡格列净和艾托格列净。 列净类药物不同于传统的降糖药,不会引起低血糖风险,还具有减重、降压、降尿酸的效果[2],能够减少蛋白尿排泄,并可显...
【1】Mann JFE, Rossing P, Bakris G, et al. Effects of semaglutide with and without concomitant SGLT2 inhibitor use in participants with type 2 diabetes and chronic kidney disease in the FLOW trial. Nat Med 2024...
[4].Ronald Goldenberg,et al.Efficacy and hypoglycaemia outcomes withonce-weekly insulin icodec versus once-dailybasal insulin in type 2 diabetes according tobaseline sodium-glucose co-transporter-2inhibitor use: ONWARDS 1-5.EASD 2024. [5].Tina Vilsboll,et al.Efficacy and hypoglycaemia outcomes wit...
(I50-200 μl) were collected into tubes containing EDTA and DPP-IV inhibitor at the following time-points: pre-dose, 5 and 30 min., and 1, 2, 4, 8, 24, 48, 72 and 96 hours post-test agent administration. Whole blood was centrifuged and subsequent plasma samples were recovered and ...
32. Xu Y, Fu EL, Clase CM, Mazhar F, Jardine MJ, Carrero JJ. GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes. Kidney Int 2022;101:36...
Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes(SUSTAIN 9): a randomised, placebo-controlled trial[J]. Lancet Diabetes Endocrinol, 2019, 7(5): 356-367. doi: 10.1016/S2213-8587(19)30066-X CrossRef Google Scholar [48] Wright AK, Carr MJ, Konto...