这种“瘦身营养素”更安全 今年6月,有“减肥神药”之称的司美格鲁肽(GLP-1)在国内获批,用于体重管理的适应症。 这是很多超重和肥胖症患者的福音,GLP-1的减重机制是控制食欲。但是,随之而来的是它的一系列负面报道,比如会引起男性性功能障碍、胃肠道不适、疲倦无力、皮肤松垮、视网膜病变和急性肾损伤等症状。此...
在胰腺α细胞中，GLP-1可降低胰高血糖素的分泌，而在胰腺β细胞中，GLP-1可促进胰岛素的分泌，二者共...
总结下来GLP-1RA具有控制血糖（空腹和餐后均可）、改善胰岛功能、改善整体代谢情况，特别适合2型糖尿病患...
Pedersen, S.D., Wharton, S., et al. 2018. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 ...
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[9] Muller, T.D., Clemmensen, C., Finan, B., DiMarchi, R.D., Tschop, M.H. 2018. Anti-Obesity Therapy: from Rainbow Pills to Polyagonists. Pharmacol Rev 70:712-746. [10] Eng, J. 1992. Exendin peptides. Mt Sinai J Med 59:147-149. ...
Convenience: Once-daily pills are easier for many patients to fit into their daily routine vs weekly injections. Reduced stigma: Some patients may feel more comfortable taking a pill vs giving themselves injections. Easier manufacturing and distribution: Pills are generally easier to make and distribu...
I don’t think there was anything surprising, but it was nice to see that patients with breast cancer who may or may not be taking these endocrine therapy pills can still lose weight with GLP-1 agonists. I would hesitate to compare the degree of weight loss that we saw in our study fi...
Nosal, who is also a family physician in the South Bronx, said that every single day she practices, she is asked about various powders, supplements, medications, pills, shots and tinctures that are marketed for patients’ health and wellness, and always, the motivations are...
These compositions take the form of solutions, suspensions, tablets, pills, capsules, sustained release formulations or powders and contain 10-95% of active ingredient, preferably 25-70%.As mentioned above, additional pharmaceutical methods may be employed to control the duration of action. Controlled...