特异性激活LCell回肠GLP-1信号导致胃胀和食欲不振 作者利用光遗传学和化学遗传学特异性激活L细胞模拟回肠L细胞分泌GLP-1。结果显示,两种方法刺激L细胞者会使胃体积增大,发生胃胀;同时增强表达GLP-1受体的回肠肌间神经元的神经元活动,导致食...
[1] Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function.Neuron (2024). DOI: https://doi.org/10.1016/j.neuron.2023.12.012 @药明康德 内容团队编辑 版权说明:本文来自药明康德内容团队,欢迎个人转发,谢绝媒体或机构未经授权以任何形式...
[1] Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function.Neuron (2024). DOI: https://doi.org/10.1016/j.neuron.2023.12.012 本文来自药明康德内容团队,欢迎个人转发至朋友圈,谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权...
[2] Drucker DJ, Habener JF, Holst JJ. Discovery, characterization and clinical development of the glucagon-like peptides. J Clin Invest. 2017;127(12):4217-4227. [3] Greiner TU, Bäckhed F. Microbial regulation of GLP-1 and L-cell biology. Mol Metab. 2016;5(9):753-758. [4] Ta...
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[3] Greiner TU, Bäckhed F. Microbial regulation of GLP-1 and L-cell biology. Mol Metab. 2016;5(9):753-758. [4] Tan Qiming, Akindehin Seun E., Orsso Camila E., Waldner Richelle C., DiMarchi Richard D., Müller Timo D., Haqq Andrea M.. Recent Advances in Incretin-Based Pha...
[3] Greiner TU, Bäckhed F. Microbial regulation of GLP-1 and L-cell biology. Mol Metab. 2016;5(9):753-758.[4] Tan Qiming, Akindehin Seun E., Orsso Camila E., Waldner Richelle C., DiMarchi Richard D., Müller Timo D., Haqq Andrea M.. Recent Advances in Incretin-Based ...
在经典观念中,远端肠道受进餐刺激分泌GLP-1,即主要分布在回肠和结肠的L细胞分泌GLP-1。而近些年的研究有了新的发现,人类不仅有肠源性的GLP-1,还有胰源性GLP-1和脑源性GLP-13,4。这背后的逻辑是,我们的GLP-1来自于由前胰高血糖素原(preproglucagon,Gcg)基因编码的胰高血糖素原,胰高血糖素原需要被PCSK 1/...
在经典观念中,远端肠道受进餐刺激分泌GLP-1,即主要分布在回肠和结肠的L细胞分泌GLP-1。而近些年的研究有了新的发现,人类不仅有肠源性的GLP-1,还有胰源性GLP-1和脑源性GLP-1 3,4 。这背后的逻辑是,我们的GLP-1来自于由前胰高血糖素原(preproglucagon, Gcg )基因编码的胰高血糖素原,胰高血糖素原需要被PC...
[34] Mace, O.J., Schindler, M., Patel, S. 2012. The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine. J Physiol 590:2917-2936. [35] Steinert, R.E., Frey, F., Topfer, A., Drewe, J., Beglinger, C. 2011. Effects...