HRs and 95% CIs for incident prostate cancer were estimated using multivariable Cox regression in 'intention-to-treat' (ITT)- and 'per-protocol'-like analyses.#Among 14,206 initiators of GLP-1RAs and 21,756 initiators of basal insulin, we identified 697 patients with prostate cancer during...
Summary Glucagon-like peptide-l(7–36)amide has been described as exerting potent glycogenic action and as stimulating glycolysis in skeletal muscle. We ex... C Fürnsinn,K Ebner,W Waldhusl - 《Diabetologia》 被引量: 902发表: 1995年 Dipeptidyl peptidase IV resistant analogues of glucagon-like...
protection of islet β cells, promotion of islet β cell proliferation and minimal side effects. Studies have found that GLP-1R is widely distributed on pancreatic
Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth Recently, pleiotropic benefits of incretin therapy beyond glycemic control have been reported. Although cancer is one of the main causes of death in diabetic patients, few reports describe the anticancer effects of incretin. Here...
[20]parveshchaudhry,mohansingh,sophieparentetal.prostateapoptosisresponse4(par-4),anovelsubstrateofcaspase-3duringapoptosisactivation.molcellbiol.2012feb;32(4):826–839. [21]patrickviatour,marie-paulemerville,vincentboursetal.phosphorylationofnf-kbandikbproteins:implicationsincancerandinflammation..trendsinbi...
GLPG0187 dose-dependently diminishes the size of the aldehyde dehydrogenase high subpopulation of prostate cancer cells. GLPG0187 treatment results in cell rounding and clumping. GLPG0187 demonstrates a dose-dependent significant reduction in tumour cell migration. GLPG0187 at all concentrations ...
Examples of obesity-related disorders include overeating and bulimia, hypertension, diabetes, elevated plasma insulin concentrations and insulin resistance, dyslipidemias, hyperlipidemia, endometrial, breast, prostate and colon cancer, osteoarthritis, obstructive sleep apnea, cholelithiasis, gallstones, heart ...
Prostate cancer is one of the most prevalent malignancies among men globally. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), primarily used for type 2 diabetes mellitus (T2DM) management, have been investigated for their potential effects on cancer risks. This systematic review and meta-...
Nucleotide sequence of Aip exon 4 and schematic structure of Aip protein. (A) Nucleotide sequence of normal (wild-type) and mutant Aip exon 4 in GH3-FTY cells. GH3-FTY cells contained heterozygous mutants of an adenine insertion at c.496 and a two base deletion at c.496-497, causing ...
GLP-1 action attenuates prostate cancer growth and progressiondoi:10.1016/s0168-8227(16)31269-4Toru ShigeokaTakashi NomiyamaShinichiro IrieTakako KawanamiYuriko HamaguchiTomoko TanakaKazuki NabeshimaMasatoshi TanakaToshihiko YanaseElsevier BVDiabetes Research & Clinical Practice...