1.Glucagon-like peptide-1 therapy in people with obesity restores natural killer cell metabolism and effector function. 2.GLP-1 analogues can actually restore anticancer NK immune cells.
(图源:A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings) 总体来说,临床I期小样本的疗效上,AMG133和Amycretin和三靶点在12周这个时间点,还没有太明显的疗效差别。而给药上,目前AMG133...
本发明涉及胰高血糖素样肽-1的肽类似物、其药学上可接受的盐、用这些类似物治疗哺乳动物的方法以及其包含所述类似物的有用的药物组合物。 The present invention relates to glucagon-like peptide-1 peptide analogs, pharmaceutically acceptable salts thereof, methods of treating mammals with these analogues and...
[4] LOVSHIN J A. Glucagon-like peptide-1 receptor agonists:a class update for treating type 2 diabetes[J]. Canadian Journal of Diabetes, 2017, 41(5): 524-535. [5] JIANG Jing-qing, FU Ling, TAN Meng-lu, CHEN Sheng-fu. Studies on glucagon like peptide-1 (GLP-1) analogues: a re...
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings. PMID: 38316982 Safety of GLP-1 Receptor Agonists and Other Second-Line Antidiabetics in Early Pregnancy. PMID: 38079178 ...
参考文献 1.Glucagon-like peptide-1 therapy in people with obesity restores natural killer cell metabolism and effector function. 2.GLP-1 analogues can actually restore anticancer NK immune cells.
[5] JIANG Jing-qing, FU Ling, TAN Meng-lu, CHEN Sheng-fu. Studies on glucagon like peptide-1 (GLP-1) analogues: a review. Journal of Chemical Engineering of Chinese Universities, 2020, 34(6): 1327-1338. DOI: 10.3969/j.issn.1003-9015.2020.06.001. ...
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings. PMID: 38316982 Safety of GLP-1 Receptor Agonists and Other Second-Line Antidiabetics in Early Pregnancy. PMID: 38079178 Glucagon-like peptide-1 receptor co-ag...
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings. PMID: 38316982 Safety of GLP-1 Receptor Agonists and Other Second-Line Antidiabetics in Early Pregnancy. PMID: 38079178 ...
[63] Pathak, V., Gault, V.A., Flatt, P.R., Irwin, N. 2015. Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice. Mol Cell Endocrinol 401:120- 129. ...