GLP-1 agonist medications work bymimickingthis hormone. In medication terms, anagonistis amanufacturedsubstance that attaches to a cell receptor and causes the same action as the naturally occurring substance. In other words, GLP-1 medications bind to GLP receptors to trigger the effects (or roles...
23. Neuen BL, Oshima M, Perkovic V, et al.. Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial. Eur Heart J 2021;42:4891-901. 10.1093/eurheartj/eh...
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et al. 2015. Impact of GLP-1 receptor agonists on blood pressure, heart rate and hypertension among patients with type 2 diabetes: A systematic review and network meta-analysis. Diabetes Res Clin Pract 110:26- 37.
GLP-1 receptor agonistLEADERLiraglutideType 2 diabetesThe prevalence of heart failure (HF) is increasing in patients with type 2 diabetes (T2D), and glucose-lowering agents have distinctive effects on the risk of developing HF that requires hospitalization. Such an increased risk has bee...
[5] Sandoval, D.A., D'Alessio, D.A. 2015. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol Rev 95:513-548. [6] Nian, M., Drucker, D.J., Irwin, D. 1999. Divergent regulation of human and rat proglucagon gene promoters in vivo. Am...
自GLP-1被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。
32. Xu Y, Fu EL, Clase CM, Mazhar F, Jardine MJ, Carrero JJ. GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes. Kidney Int 2022;101:360-8. 10.1016/j.kint.2021.10.033 ...
[5] Sandoval, D.A., D'Alessio, D.A. 2015. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol Rev 95:513-548. [6] Nian, M., Drucker, D.J., Irwin, D. 1999. Divergent regulation of human and rat proglucagon gene promoters in vivo. Am...
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice[J]. Diabetes,2009, 58(4):975-83. [27] Marso SP,Lindsey JB,Stolker JM,et a1.Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase...