如前所述,多个GLP-1R药物已经上市,主要用于2型糖尿病治疗。近年来,也出现了基于GLP-1R的单抗、双抗等生物药,如GCGR x GLP-1R、GDF-15 x GIP-1R、FGF21 x GIP-1R双激动剂(表1)。这些基于GLP-1R的靶向药物有望更有效地管理血糖和调节血脂,同时延缓2型糖尿病患者的相关并发症,并改善患者的生活质量。这些探...
GLP⁃1RA可有效降低血糖，能部分恢复胰岛β细胞功能，长期使用具有心血管与肾脏获益。其还有降低体重，改...
large employee populations and a lot of control over their benefits and coverage have a vested interest in covering these drugs for weight loss, and a lot of them want to. 79% of HR decision-makersagreethat GLP-1 coverage would improve employees' long-term wellness, and 77% agree that ...
Since aging process is associated with loss of muscle (lean body) mass which increases risk of sarcopenia and since weight loss programs routinely induce loss in both fat and lean masses, weight loss intervention that targets fat mass reduction while preserving lean body mass is clearly needed in...
Weight loss with subcutaneous semaglutide versus other glucagon-like peptide 1 receptor agonists in type 2 diabetes: A systematic review [J]. Intern Med J, 2023, 53(8): 1311- 1320. [32] Yuan X, Gao Z, Yang C X, et al. Comparing the effectiveness of long-term use of daily and ...
(Thermo Fisher). CHO-AM1D cells stably expressing monkey GLP-1R cells were cultured in DMEM supplemented with 1% PSG, 10% dialysed FBS, 1% NEAAs, 1 mM sodium pyruvate, 1% sodium hypoxanthine and thymidine supplement (HT supplement) and 400 mg ml−1hygromycin (Thermo Fisher). HEK ...
While the DWLS spectrum is broad and contains several providers who offer GLP-1 RAs strictly as a supplement to lifestyle therapy [7,15], many services still appear to deliver GLP-1 RA prescriptions with little to no follow-up care [9,14]. In regard to allowing unsuitable patients to ...
VITAMIN B12 is a dietary supplement utilized in many areas of the body principally for the proper function of your red blood cells, nerve cells, energy levels and mood. Additionally it is used to supplement B12 when other drugs may possibly decrease its level. ...
As we sought to test the effect of more aggressive GcgR potency on both weight loss and glycemic control, we explored additional mutations to increase the GcgR potency of 13 with a more balanced ratio with respect to GLP-1R potency. A Q17K mutation (14) and a A18Y mutation (15) ...
eMethods Supplement 2. Data Sharing Statement 1. Tsapas A, Avgerinos I, Karagiannis T, et al. Comparative effectiveness of glucose-lowering drugs for type 2 diabetes: a systematic review and network meta-analysis. Ann Intern Med. 2020;173(4):278-286. doi:10.7326/M20-0...