[32]Barragan, J.M., Rodriguez, R.E., Eng, J., Blazquez, E. 1996. Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and hear...
A Blood Test for Alzheimer Disease, Repurposing GLP-1s, and Wildfire Smoke—Highlights From the AAIC Simpler diagnostic testing for Alzheimer disease, the latest findings about approved treatments as well as potentially effective new ones, and possible risk factors were among the topics cov...
A Blood Test for Alzheimer Disease, Repurposing GLP-1s, and Wildfire Smoke—Highlights From the AAICalzheimer's diseaseblood testssmokeThis Medical News article is an interview about the latest findings presented at the recent Alzheimer's Association International Conference....
W., Nauck, M.A. 1996. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. ...
[76] Kastin, A.J., Akerstrom, V., Pan, W. 2002. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci 18:7-14. [77] Salinas, C.B.G., Lu, T.T., Gabery, S., Marstal, K., Alanentalo, T., Mercer, A.J., et al. 2018. Integra...
利用这个模型,发现Exendin-4能增加幼年人胰岛的β细胞增殖,但不能增加成年人胰岛的β细胞增殖[31]。值得注意的是,Eexendin-4诱导的β细胞增殖的年龄依赖性下降与GLP-1R表达的变化无关,同时提示Exendin-4保存了对成年胰岛的促胰岛素分泌功能[31]。然而,仅在未成年人胰岛而非成人胰岛中,Exendin-4可刺激钙调磷酸酶/...
在混合膳食试验(mixed-meal test, MMT)之后,可以观察到注射80和150毫克剂量SAR441255的受试者餐后血浆葡萄糖、胰岛素和C肽水平呈剂量依赖性降低,而安慰剂组则略有增加。在不良反应方面,单剂量高达150 mg的SAR441255耐受性良好,6名接受此剂量的受试者中有3名出现恶心,但程度均为轻度。心率和收缩压的变化与在食...
Acting as a GLP-1 receptor agonist, it cleverly replicates a hormone that your body already uses to regulate blood sugar, making it an invaluable tool in your weight loss arsenal. Semaglutide is administered by injecting the medication into the fatty area around your love handles, using a short...
Professor Foltynie added, "It is not yet clear whether there may be a subgroup of people with Parkinson's disease who may get benefit from the use of exenatide. We will continue to scrutinize the data to see whether abnormal blood test results such as having 'pre-diabetes' might predict ...
body weight (P<0.001), blood glucose levels in OGTT (P<0.001), HbA1c(P<0.05) and improved insulin resistance (P<0.01). Notably, it increased peripheral adipocyte density and resolved hepatic steatosis. The efficacy of SAL0112 was found to be comparable to that of Danuglipron and ...