Impact of GLP-1 Drugs on Hospitals’ Future | AHA Comparison of Ozempic and Mounjaro: A Guide to Weight-Loss Drugs | Scientific American Medications for Binge Eating Disorder Treatment Why Your Cardiologist May Prescribe Semaglutide (Wegovy) 【独家稿件声明】本文为美国续航教育(Forward Pathway LLC,官...
在体外已经证实了KATP通道活性在介导GLP-1释放中的重要性,同时也证实人L-细胞中存在KATP通道的Kir6.2/SUR1通道复合物[31],但KATP通道的Kir6.2/SUR1通道复合物是否在人体中介导GLP-1释放这一过程的作用还有待证实。 图2 L-细胞内营养物质刺激GLP-1分泌的示意图 CICR:钙诱导的钙释放;LCFA:长链脂肪酸;GLUT2:葡...
GIP刺激迷走神经传入传递,随后激活迷走传出神经元和肠神经元,释放乙酰胆碱和/或GRP来刺激远端肠道释放GLP-1,触发GLP-1分泌,而营养物质如能到达远端肠道时,与L-细胞的直接接触也会触发GLP-1分泌进入循环。 02 中枢GLP-1分泌的内分...
胰高糖素样肽-1 (GLP-1) 自被发现以来,已然成为一种“多面手”激素——其对多种代谢的影响接二连三的被发现,远远超出了肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂类药物逐渐成为更多新兴领域治疗的冉冉之“星”,如脂肪肝、肥胖和神经退行性疾病等。时值利拉鲁肽在我国上市10周年,司美格鲁肽新...
图2 L-细胞内营养物质刺激GLP-1分泌的示意图 CICR:钙诱导的钙释放;LCFA:长链脂肪酸;GLUT2:葡萄糖转运体2;GLP-1:胰高糖素样肽-1;GLP-2:胰高糖素样肽-2;OXM: 胃泌酸调节素;Trpc3:瞬时受体电位通道3;VDCC:电压门控钙通道;SGLT1:钠-葡萄糖共转运体1。
GLP-1类减重药正在引领一场新的医药革命。当我们追根溯源的时候,才发现它们的研发历史竟是由一系列“逆袭”的故事串成的。 最早发现、研究GLP-1的科研人员在学术会议上遭受冷遇,他们的报告现场门可罗雀。在阐明GLP-1生物机理方面做出关键贡献的女化学家Svetlana Mojsov几乎被历史遗忘。27年前,她决定站出来,为自己...
[4] Rowland, N.E., Crews, E.C., Gentry, R.M. 1997. Comparison of Fos induced in rat brain by GLP-1 and amylin. Regul Pept 71:171-174. [5] Gil-Lozano, M., Perez-Tilve, D., Alvarez-Crespo, M., Martis, A., Ferna...
comparison of an NLRP3 inhibitor to a glucagon like peptide-1 receptor agonist, semaglutide (Wegovy), in the DIO model allowed an appreciation of the relative efficacy of these two therapeutic strategies on obesity, its associated systemic inflammatory response, and cerebral gliosis. We show that...
[12] Parkes, D., Jodka, C., Smith, P., Nayak, S., Rinehart, L., Gingerich, R., et al. 2001. Pharmacokinetic Actions of Exendin-4 in the Rat:Comparison With Glucagon-Like Peptide-1. Drug Development Research 53:260-267.
comparison of two classes of drugs in clinical use becomes a hot research topic.A head to head comparison study has shown that,compared with DPP-4 inhibitor sitagliptin,GLP-1 analogue liraglutide shows better blood glucose control,weight loss,and β-cell function improvement,as well as h...