[19] Gosmain, Y., Cheyssac, C., Heddad Masson, M., Dibner, C., Philippe, J. 2011. Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in alpha-cell differentiation, glucagon biosynthesis and secretion. Diabetes Obes Metab 13 Suppl 1:31-38. [...
[19] Gosmain, Y., Cheyssac, C., Heddad Masson, M., Dibner, C., Philippe, J. 2011. Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in alpha-cell differentiation...
激素原转化酶可将胰高糖素原分子切成不同大小的肽段,包括含肠高血糖素相关胰多肽(GRPP; 氨基酸片段1 - 30)、胰高糖素(氨基酸片段33 - 61)、胃泌酸调节素(OXM;氨基酸片段 33 - 69)的肠高血糖素(氨基酸片段1 - 69)和含胰高糖素样肽1 (GLP-1;氨基酸片段 72-107/108)、胰高糖素样肽2 (GLP-2;氨基...
[3] Saeid, Saghahazrati, Seyed Abdul Majid, Ayatollahi, Farzad, Kobarfard, Bagher, Minaii Zang.The Synergistic Effect of Glucagon-Like Peptide-1 and Chamomile Oil on Differentiation ofMesenchymal Stem Cells into Insulin-Producing Cells. [J]. Cell journal,2020,21(4):371-378....
Secretion of GLP-1 has been suggested to be impaired in T2D and in conditions associated with hyperlipidemia and insulin resistance. Further, recent studies support lipotoxicity of GLP-1-producing cells in vitro. However, little is known about the regulation of L-cell viability/function, the ...
[3] Saeid, Saghahazrati, Seyed Abdul Majid, Ayatollahi, Farzad, Kobarfard, Bagher, Minaii Zang.The Synergistic Effect of Glucagon-Like Peptide-1 and Chamomile Oil on Differentiation ofMesenchymal Stem Cells into Insulin-Producing Cells. [J]. Cell journal,2020,21(4):371-378....
[3] Saeid, Saghahazrati, Seyed Abdul Majid, Ayatollahi, Farzad, Kobarfard, Bagher, Minaii Zang.The Synergistic Effect of Glucagon-Like Peptide-1 and Chamomile Oil on Differentiation ofMesenchymal Stem Cells into Insulin-Producing Cells. [J]. Cell journal,2020,21(4):371-378....
了解GLP-1影响体重的相关机制。 自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用...
cell membrane, while also activate the voltage-dependent Ca2+ channel, causing a Ca2+ inflow and the generation of action potentials [15]. In addition, PKA can also promote Ca2+ release by activating inositol triphosphate (IP3). The activated EPAC2 can further activate Ras protein 1 and ...
这表明,GLP-1对肾功能的影响可能是短暂的。但另一针对2型糖尿病患者的研究中,利拉鲁肽的利钠作用在治疗3周后持续存在[87]。 在大鼠中,GLP-1诱导的利钠和利尿伴随着肾血流量和肾小球滤过率增加[81,82],可能是GLP-1增加了肾入球小动脉的扩张而介导。肾脏去神经会导致GLP-1不能增加肾小球滤过率,降低GLP...