[0307] 所述免疫球蛋白Fc区域可以具有二聚体 (dimeric form)形式,胰高血糖素/GLP‑ 1/GIP三重激动剂的一个分子可以以共价键方式连接至具有二聚体形式的一个Fc区域,此 时,所述免疫球蛋白Fc和胰高血糖素/GLP‑1/GIP三重激动剂可以通过非肽聚合物互相连 接。另外,胰高血糖素/GLP‑1/GIP‑三重激动...
Noun1. glyph- glyptic art in the form of a symbolic figure carved or incised in relief glyptic art,glyptography- carvings or engravings (especially on precious stones) Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. ...
cysteine homologues to the C terminus of the peptide to facilitate disulfide conjugation to the linker (Extended Data Fig.2b–d). Moreover, we confirmed that the conjugate is degraded in vitro by incubation under high concentrations of glutathione (Extended Data Fig.2e). We observed that GLP-1...
A synthetic polymer and/or a protein, e.g transferrin or albumin, is covalently or non-covalently bound to the fusion peptide to form the conjugate molecule. Component (II) is preferably a full or partial version of IP2 (intervening peptide 2). A preferred embodiment comprises the sequence ...
[8].Astrazeneca, 20-F Form 2016, https://www.astrazeneca.com/content/dam/az/Investor_Relations/Annual-report-2016/AZ_AR2016_Full_Report.pdf FDA于不久之前的2017年10月20日批准了改良的艾塞那肽缓释微球注射用混悬液,商品名BydureonBcise。BydureonBcise与先前Bydureon的差别在于,BydureonBcise是一种以中...
(0.9 g, 0.3 mmole) in the chloride ion form is placed in a reaction vessel of an Advanced ChemTech Peptide Synthesizer Model 200 programmed to perform the following reaction cycle: (a) methylene chloride; (b) 33% trifluoroacetic acid in methylene chloride (2 times for 1 and 15 min each)...
[6].Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results. [7].Astrazeneca, 20-F Form 2012, [8].Astrazeneca, 20-F Form 2016, FDA于不久之前的2017年10月20日批准了改良的艾塞那肽缓释微球注射用混悬液,商品名BydureonBcise。BydureonBcise与先前Bydureon的差别在于,Bydureon...
gip是一种由从小肠的k细胞分泌的42个氨基酸组成的激素,其具有通过根据血糖浓度调节从胰脏的胰岛素或胰高血糖素的分泌来维持血糖的体内稳态,并且,已有报告其与glp-1相同具有通过中枢神经和迷走神经抑制食物摄取的功能。 3、对于glp-1而言,由于通过根据血糖的胰岛素分泌的血糖降低和通过食物抑制的体重降低效果,作为糖尿病...
[8].Astrazeneca, 20-F Form 2016, https://www./content/dam/az/Investor_Relations/Annual-report-2016/AZ_AR2016_Full_Report.pdf FDA于不久之前的2017年10月20日批准了改良的艾塞那肽缓释微球注射用混悬液,商品名BydureonBcise。BydureonBcise与先前Bydureon的差别在于,BydureonBcise是一种以中链甘油三酯为赋...
Increasing how full you feel after eating (satiety): GLP-1 affects areas of your brain that processes hunger and satiety. trigger:触发,引发 insulin:胰岛素 pancreas:胰腺 glucose:葡萄糖 secretion:分泌 bloodstream:体内循环的血液 satiety:/səˈtaɪəti/满足 ...