Cao C, Yang S, Zhou Z. GLP-1 receptor agonists and pancreatic safety concerns in type 2 diabetic patients: data from cardiovascular outcome trials. Endocrine. 2020 Jun;68(3):518-25. Lee J, Kim R, Kim MH, et al. Weight ...
GLP-1具有葡萄糖浓度依赖性降糖作用 作为一种肠源性激素,GLP-1是在营养物质特别是碳水化合物的刺激下才释放入血的,其促胰岛素分泌作用呈葡萄糖浓度依赖性,Nauck等[6]对10例血糖控制不佳的2型糖尿病患者进行了研究,并在空腹状态下分别给予患者GLP-1或安慰剂,结果显示,患者在输注GLP-1后,其胰岛素和C肽水平显著...
[5] Vilsbøll, T et al. “Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.” Diabetes vol. 50,3 (2001): 609-13. doi:10.2337/diabetes.50.3.609 [6] Toft-Nielsen, M B et al. “Determinants of the impaired secretion of...
W., Nauck, M.A. 1996. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 81:327-332. ...
[6] Vilsboll, T., Agerso, H., Krarup, T., Holst, J.J. 2003. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 88:220-224. [7] Bettge, K., Kah...
Orskov, C., Creutzfeldt, W., Nauck, M.A. 1996. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 81:327-332...
了解GLP-1影响体重的相关机制。 自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用...
2.Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab. 2001 Aug;86(8):3717-23. 3.GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PR...
[18] Simó, Rafael, and Cristina Hernández. "GLP-1R as a target for the treatment of diabetic retinopathy: friend or foe?." Diabetes 66.6 (2017): 1453-1460.[19] Meier, Juris J. "GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus." Nature Reviews ...
[6] Vilsboll, T., Agerso, H., Krarup, T., Holst, J.J. 2003. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 88:220-224. [7] Bettge, K., Kahle, M., Abd El Aziz, M.S., Meier, J.J., Na...