probably unsurprisingly, was about GLP-1 receptor agonists, or glucagon-like peptide-1 receptor agonists, like semaglutide and tirzepatide. This drug class is approved for use in type 2 diabetes, weight loss, and cardiov...
停药后体重反弹导致对于GLP-1药物的依赖性,导致了保险覆盖方面的巨大问题。患者终生用药,将造成巨大的经济压力,而且在停药后健康计划是否继续承担GLP-1药物费用,也是行业内关注的焦点问题。 5 第三战场的开辟 GLP-1多肽已经针对2型糖尿病和肥...
体重反弹似乎是GLP-1他日“亢龙有悔”的先兆,如果GLP-1的best-in-class产品出炉,甚至新一代的减肥药物能够迅速开发出来,直指肥胖症的病理,在实现一定减重的基础上能够有效巩固体重减轻,避免停药后的体重明显反弹,那么目前的GLP-1药物也有可能成为千帆竞渡的医药历史中的明日黄花。 参考文献: 1.Anderson, L. A. ...
In one arm of the study, researchers compared more than 36,000 people prescribed a GLP-1 drug against more than 234,000 patients taking DPP-4 inhibitors for their diabetes between 2007 and 2020. In the second arm, the team compared more than 32,000 GLP-1 patients against more than 96,...
胰升糖素样肽-1利拉鲁肽糖尿病,2型研究证实,新型胰升糖素样肽-1(GLP-1)类似物可以解决糖尿病治疗中存在的多种问题,因而受到各国学者的广泛关注.本文概括了GLP-1的生理作用和长效人GLP-1类似物利拉鲁肽的延长作用机制,同时重点介绍了利拉鲁肽的最新基础与临床研究进展.%The novel drug class of Glucagon-...
9.O’Connor, A. M. The Surprising Truth About Obesity Drug Dropouts. HealthCentral. 10. 12. 2023. *声明:本文仅是介绍医药疾病领域研究进展或简述研究概况或分享医药相关讯息,并非也不会进行治疗或诊断方案推荐,也不对相关投资构成任何建议。内容如有疏漏,欢迎沟通指出!
Snapshot from https://www.diabetesincontrol.com/eli-lilly-cuts-deal-for-the-rights-to-a-new-diabetes-drug-from Eli Lilly尽管错失了与约翰·恩博士的直接合作,却从未走远,并一直关注着Exendin-4的进展。Eli Lilly当时也有自己的GLP-1类似物项目,但在临床上并未达到预期。于是,在2002年[3],Eli Lilly抓住...
2019年9月20日,在消耗了一张珍贵的优先审评券后,司美格鲁肽片仅用了6个月时间,便获得FDA批准上市,美国媒体界将其称为“'holy grail' diabetes drug”,意为:糖尿病药物中的“圣杯”,或是“杀手锏药物”。 为何能获此殊荣?其中一个原因是,司美格鲁肽片用口服的方式,达到了注射的疗效。
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/rare-pediatric-disease-priority-review-vouchers;https://www.fiercepharma.com/pharma/ultrarare-disease-drug-ascends-to-top-most-expensive-pharmacy-drugs-u-s-2021;等等。
The GLP-1 drug class took the market by storm. Now that it’s showing effectiveness against other diseases, here’s how our thinking has evolved. Weight loss drugs generated tremendous attention in 2023 and that excitement is still growing. Biotech experts have called glucagon...