The substance refers to a dissolved pharmacological compound, including a GLP-1 and / or its salt activator. The content of mequinone varies from 1 mg / ml to 5 mg / ml, while the activator of GLP-1 lacks 36exendina-4 (1-39) - lys6-nh2, exendina-4, etc. It also includes ...
2 Bezin et al. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Bezin et al. 2022 Diabetes Care. 2022 Nov 10; dc221148. doi: 10.2337/dc22-1148. (Online ahead of print) 3 Alves C, Batel-Marques F, Macedo AF. A meta-analysis of serious adverse events reported with exenatid...
When GLP-1 RAs were introduced as novel agents to treat type 2 diabetes, there was uncertainty about several potential adverse effects such as acute pancreatitis, pancreatic cancer, and thyroid cancer [102,103]. The availability of large databases from randomized CV outcome studies that defined pan...
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C. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 141, 150–156 (2011). Article CAS PubMed Google Scholar Noel, R. A., Braun, D. K., Patterson, R. E. & Bloomgren, G. L. Increased risk of acute pancreatitis and biliary ...
The results indicate that incretins are involved in the action of Syn1 and Syn2 or that they may even be their target. No changes were observed in key hormones regulating metabolism (insulin, glucagon, corticosterone, thyroid hormones, and leptin) or in metabolic indices (glucose, NEFA, ...
The GIPR gene is expressed in the pancreas, stomach, small intestine, adipose tissue, adrenal cortex, pituitary, heart, testis, endothelial cells, bone, trachea, spleen, thymus, lung, kidney, thyroid, and several regions in the Biological Actions of GIP The actions of GIP on the pancreatic ...
procedural factors (i.e., thyroid surgery associated with risk for nausea, ketamine associated with nausea and secretions), and/or medications associated with delayed gastric emptying (opioids, anticholinergics, antidepressants, beta-blockers, calcium channel blockers, DPP-IV inhibitors, and antacids)...
Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas Mod. Pathol., 28 (3) (2015), pp. 391-402 CrossrefView in ScopusGoogle Scholar [46] C. Saponaro, V. Gmyr, J. Thévenet, E. Moerman, N. Delalleau, G. Pasquetti, et al. The GLP1R agonis...
The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes