就在哈本纳发现GLP-1作用的同时,丹麦的外科医生、生理学家詹斯·霍尔斯特 (Jens Juul Holst) 通过胃溃疡手术方面的工作也独立地发现了GLP-1是一种新的肠促胰素。霍尔斯特观察到,他的许多接受肠道溃疡手术的患者,在餐后会出现胰岛素峰值和低血糖的情况。霍尔斯特最终在人体血液中发现了一类...
drugs in clinical use becomes a hot research topic.A head to head comparison study has shown that, compared with DPP-4 inhibitor sitagliptin, GLP-1 analogue liraglutide shows better blood glucose control, weight loss, and 尾-cell function improvement, as well as higher patient treatment ...
肾脏去神经会导致GLP-1不能增加肾小球滤过率,降低GLP-1的利钠和利尿作用[81],这也表明GLP-1的利钠利尿作用可能是由于抑制近端小管的钠重吸收,并强调GLP-1需要完整的肾神经支配来增加肾小球滤过。在啮齿动物和人的研究中表明GLP-1R在肾血管系统中表达[88]。GLP-1、exendin-4和DPP-4抑制剂西格列汀降低大鼠[...
肾脏去神经会导致GLP-1不能增加肾小球滤过率,降低GLP-1的利钠和利尿作用[81],这也表明GLP-1的利钠利尿作用可能是由于抑制近端小管的钠重吸收,并强调GLP-1需要完整的肾神经支配来增加肾小球滤过。在啮齿动物和人的研究中表明GLP-1R在肾血管系统中表达[88]。GLP-1、exendin-4和DPP-4抑制剂西格列汀降低大鼠[...
4. Marre M, Shaw J, Brändle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes(LEAD-1 SU). Diabet...
【关键词】2 型糖尿病;GLP-1 类似物;司美格鲁肽;降糖药物Research progress of GLP-1 analogue smeglutide LIU Tian-yang.Department of Endocrinology, branch of Tianjin Third Central Hospital, Tianjin 300250,China.【Abstract】Smeglutide is a new long-acting GLP-1 analogue independently developed by ...
NGELA V,NAVARRO J,HERRERO-CERVERA A,et al.The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype[J].Diabetologia,2017,60(9):1801-1812.Vinue A, Navarro J, Herrero-Cervera A, Garcia-Cubas M, Andres-Blasco I, Martinez-Hervas S, ...
well as in combination for cardiometabolic diseases such as type-2 diabetes, as well as for obesity. ECC5004 further strengthens our existing pipeline addressing both incretin and non-incretin pathways, including our GLP-1/glucagon dual agonist [AZD9550] and long-acting amylin analogue [AZD6234]....
【关键词】2型糖尿病；GLP-1类似物；司美格鲁肽；降糖药物 Research progress of GLP-1 analogue smeglutide LIU Tian-yang.Department of Endocrinology， branch of Tianjin Third Central Hospital， Tianjin 300250，China.【Abstract】Smeglutide is a new long-acting GLP-1 analogue independently developed by...
It is an object of the invention to improve the ability of a GLP-1 analogue type drugs to resist digestion-based degradation and thereby provide longer lasting effective glucose management in users. Certain known GLP-1 receptor agonists such as Trulicity™ are fusion proteins that include two ...