这项研究的目的是研究SGLT-2抑制剂、GLP-1受体受体激动剂和二肽基肽酶-4(DPP-4)抑制剂在降低2型糖尿病成年人高钾血症的风险方面的比较有效性。 该研究是基于人群的队列研究,采用主动对照,新用户设计。参与者1:1倾向评分匹配了...
GLP-1 receptor agonistDPP-4 inhibitorincretin enhancerincretin mimeticstype 2 diabetes mellitusmode of actionOver the last few years, the incretin-based therapies have emerged as important agents in the treatment of type 2 diabetes (T2D). These agents exert their effect via the incretin system, ...
这项研究的目的是研究SGLT-2抑制剂、GLP-1受体受体激动剂和二肽基肽酶-4(DPP-4)抑制剂在降低2型糖尿病成年人高钾血症的风险方面的比较有效性。 该研究是基于人群的队列研究,采用主动对照,新用户设计。参与者1:1倾向评分匹配了新开始服用SGLT-2抑制剂与DPP-4抑制剂的2型糖尿病成年人(n=778 908),GLP-1受体...
暴露:GLP-1受体激动剂治疗与DPP-4抑制剂相比。 主要结果和测量指标:比较GLP-1受体激动剂治疗患者和DPP-4抑制剂治疗患者的全因死亡率、脓毒血症和感染相关死亡率以及与主要心脑血管不良事件相关死亡率。使用倾向评分加权,缓解组间协变量之间的不平衡。 结果:在纳入研究的27279例患者中,DPP-4抑制剂组26578例(1444...
While the usefulness of majority of anti-DN strategies require further investigation and development, the incretin pathway modulators (GLP-1 agonist and DPP-IV inhibitors) and SGLT2 inhibitors offer the best potential in the management of DN. Up-regulation of SGLT2 content and activity is at the...
M. Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis. Physiol. Behav. 114−115, 38–41 (2013). Google Scholar Gunturu, S. The potential role of GLP-1 agonists in psychiatric disorders: a paradigm shift in mental ...
Fig. 1 Molecular basis of incretin axis: DPP-4 proteins consist of a short intracellular domain (6 amino acids), a transmembrane domain, and a large extracellular domain. The extracellular domain is responsible for the enzymatic cleavage of the substrates and binding to its ligands including fibro...
The aim of the study was to investigate the effects of the DPP-4 inhibitors and GLP-1R agonist, exendin-4 on the mechanism(s) of endothelium-dependent relaxation in rat mesenteric arteries exposed to high glucose concentration (40 mM). Organ bath techniques were employed to investigate vascular...
为了解决这个问题,科学家们发明了一种叫做GLP-1受体激动剂(GLP-1 receptor agonist)的药物。这种药物能够模拟GLP-1的结构和功能,与人体内的GLP-1受体结合,从而发挥类似于GLP-1的作用。与GLP-1不同的是,GLP-1受体激动剂具有更长的半衰期,能够在人体内持续存在和发挥效果。因此,GLP-1受体激动剂能够有效地降低血糖...
1recept()ragonist;Dipeptidyl— 【Keywords】lm:retins;Diabetes peplidase4inhibitor 肠促胰素,包括胰升糖素样肽1(GLP一1)和肠抑胃 肽(GIP),在维持血糖稳定方面起关键作用。临床研 究表明,肠促胰素可刺激胰岛素分泌,抑制胰升糖素分 泌,这些作用均依赖于葡萄糖。GLP一1还可延缓进食 后的胃排空速度,抑制食欲...