Expression of functional soluble human alpha-globin chains of hemoglobin in bacteria. Protein Expr. Purif. 2000; 20 :37–44.K. Adachi, T. Yamaguchi, Y. Yang, P.T. Konitzer, J. Pang, K.S. Reddy, M. Ivanova, F. Ferrone, S. Surrey, Expression of functional soluble human a-globin ...
Phenotype studies still occupy a key position in the diagnosis of hemoglobin (Hb) disorders. An additional dimension to the methods for diagnosis of Hb disorders which are mostly based on difference in charge of the Hb molecules may be brought by studying some properties of the globin chains. ...
The β and δ chains of hemoglobins A and Aare very similar in structure and are encoded by genes that are tightly linked, yet in the red cell β chain production is 40 fold greater than production of the δ chain, providing an excellent model for studying the control of gene expression...
They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control is dependent on ...
The Synthesis of Fetal Hemoglobin Types in red Blood Cells and in BFU-E Derived Colonies from Peripheral Blood of Patients with Sickle Cell Anemia, β+- an... The biosynthesis of two types of human fetal hemoglobin (Hb F), namely Hb F with Gγ chains having glycine in position 136 and...
18.The human genome includes five copies of the gene that produces beta-globin. 人类基因组包括了5个β球蛋白基因的拷贝。 19.The globin chains produced are too long to form functional hemoglobin. 20.Our skeletal muscles make myoglobin, a single globin protein ancestral to hemoglobin, which helps...
Oxidized hemoglobin and its products were followed with spectrophotometry, LC–MS/MS analysis and detection of the cross-linking of globin chains in complicated atherosclerotic lesions of the human carotid artery and the hemorrhaged cerebrospinal liquid of preterm infants. The vascular pathophysiologic ...
Hemoglobins, XXXV: The Sequence of the ßA- und ßB-Chains of the Hemoglobins of the Carp(Cyprinus carpio L.)Summary: The primary structure of the 0A- and0B-chains from both main components of thetetrameric hemoglobins from carp is given. Thesequences were found by automatic ...
the albuminous part of the complex protein hemoglobin, which includes four globin chains. Up to 30 percent of the proteinaceous nitrogen of globin is found in the diamino acids (arginine, lysine, and histidine). This is also characteristic of the histones; however, in contrast to the latter,...
It is estimated that there are 200 million carriers of beta thalassemia gene all over the world, nine million are estimated in Pakistan.2,3 Thalassemias are genetic disorders characterized by reduced synthesis of either beta ([beta]) or alpha ([alpha]) globin chains of hemoglobin. FREQUENCY O...