The first generation ofsulfonylureasare rarely ever used these days and include drugs like tolbutamide, chlorpropamide and tolazamide. The second generationsulfonylureasinclude glimepiride, glyburide (glibenclamide), glipizide, and gliclazide and are widely used as these are much safer and more potent t...
Increased risk of overall mortality in patients with type 2 diabetes receiving glipizide, Glyburide, and Glimepiride vs. Metformin. A Retrospective AnalysisK.M., PantaloneM.W., KattanC., YuB.J., WellsS., ArrigainA., JainA., Atreja
glimepiride; aspirin; Lantus (insulin glargine); hydrochlorothiazide; Aspirin Low Strength (aspirin); levothyroxine; insulin; atorvastatin; simvastatin; stribild; Lipitor (atorvastatin); Bydureon (exenatide); glyburide; losartan; carvedilol; Trulicity (dulaglutide); metformin; Crestor (rosuvastatin); gabapenti...
function. Glimepiride should be avoided in patients with GFR <30 mL/min (Ioannidis, 2014). Glibenclamideorglyburideis metabolized by the liver into active metabolites that are eliminated equally in urine and bile. Therefore, the SU is contraindicated in patients with eGFR <60 mL/min (CKD stage...