(Panel A) The structure of two second-generation drugs, glipizide and glimepiride, that belong to the sulfonylurea class of compounds that have proven to be effective in treating type 2 diabetes. The inset “box” contains the structure of the sulfonylurea radical which is the “active” portion...
function. Glimepiride should be avoided in patients with GFR <30 mL/min (Ioannidis, 2014). Glibenclamideorglyburideis metabolized by the liver into active metabolites that are eliminated equally in urine and bile. Therefore, the SU is contraindicated in patients with eGFR <60 mL/min (CKD stage...