Avoid drinking alcohol. It lowers blood sugar and can cause side effects. Avoid driving or operating machinery until you know how this medicine will affect you. Glipizide side effects Get emergency medical help if you havesigns of an allergic reaction to glipizide:hives; difficulty breathing; swell...
Potential pharmacokinetic interaction with other protein-bound drugs.Use with caution with protein-bound drugs.Specific DrugsDrug Interaction Comments ACE inhibitors May increase hypoglycemic effect Observe closely when concurrent therapy is initiated or discontinued Alcohol May either potentiate or weaken...
C. Jr. (1994) Lack of interaction between glipizide and co-trimoxazole. J. Clin. Pharmacol. 34, 997-1002.Kradjan, W.A., Witt, D.M., Opheim, K.E. and Wood, F.C. Jr., Lack of interaction between glipizide and cotrimoxazole. J. Clin. Pharmacol., 1994, 34(10), 997....
The combination of alcohol abuse andglipizidemay have caused fatalhepatic failure. • A 50-year-old obese woman taking glipizide 5 mg/day who had been drinking a bottle of rum daily for 2 months developed an acute hepatitis and died (92A). The viral hepatitis profile was negative. At auto...
Hypoglycemia may be difficult to recognize in the elderly, and in people who are taking beta-adrenergic blocking drugs. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when alcohol is ingested, or when more than one glucose-lowering drug...
porphyria and disulfiram-like reactions have been reported with sulfonylureas. In the mouse, glipizide pretreatment did not cause an accumulation of acetaldehyde after ethanol administration. Clinical experience to date has shown that glipizide has an extremely low incidence of disulfiram-like alcohol ...
Alcohol, beta-blockers, clonidine, and reserpine may lead to either potentiation or weakening of the glucose-lowering effect. Increased frequency of monitoring may be required when GLUCOTROL XL is co-administered with these drugs. The signs of hypoglycemia may be reduced or absent in patients taki...
Alcohol, beta-blockers, clonidine, and reserpine may lead to either potentiation or weakening of the glucose-lowering effect. Increased frequency of monitoring may be required when glipizide extended release tablets are co-administered with these drugs. ...
Drug interaction 1. In combination with the following drugs, can increase the occurrence of hypoglycemia: ① inhibit sulfonylureas excreted in the urine, such as gout, methylsulfonamide, allopurinol. ② Drugs that delay the metabolism of sulfonylureas, such as alcohol, H2 blockers (cimetidine, ...
Subsequent study shows no interaction of GPZ with PLGA (FT-IR study). Various formulation parameters such as stirring speed (300鈥 3000 rpm), drug:polymer ratio (1:4 to 2:1), with addition of surfactants (0.5%, w/v polyvinyl alcohol/polysorbate-80) were studies for particle size, drug ...