产品简介 MDLMFCD00072159 ECEINECS 249-427-6 别名格列甲嗪 CAS29094-61-9 分子式C21H27N5O4S 分子量445.54 纯度HPLC≥98% 单位瓶 SMILESO=C(C1=NC=C(C)N=C1)NCCC2=CC=C(S(=O)(NC(NC3CCCCC3)=O)=O)C=C2 靶点Potassium Channel 规格50mg 100mg 10mM*1mL (in DMSO) ...
与速释片相比,5 mg格列吡嗪控释片组患者空腹胰岛素和C-肽水平更低。两种剂型的格列吡嗪治疗后,受试者糖耐量实验后的血-糖反应相似;但是,在8周治疗阶段结束时,格列吡嗪控释片的血清胰岛素(P<0.01)和C肽反应(P<0.05)低于速释片治疗...
【药物别名】美吡达、依必达 Minidiab 【分子式成分】本品化学名为1-环己基-3-(4-(2-(5-甲基吡嗪-2-甲酰胺基)乙基)苯磺酰)脲,其分子式为C21H27N5O4S,分子量为445.54。 【制剂规格】片剂:2.5mg、5mg 。本品为白色片,在水中迅速崩解。 【药理毒理】本品为第二代磺酰脲类口服降血糖药。即能促进胰脏β...
长期服用可显著降低其胃肠滞留,致血浆浓度降低,格列吡嗪的药代动力学在5-60 mg的剂量范围呈线性关系,因为血浆药物浓度与剂量成比例增加。格列吡嗪主要通过肝脏生物转化而消除,少于10%的剂量以未变化的药物形式经尿和粪便排泄:大约90%的剂量以生物转化产物经尿(80%)和粪便(10%)排泄。格列吡嗪的主要代谢物为芳香羟基...
格列吡嗪(5 mg/kg/天,连续10天)的饮食给药增加了分离和纯化的小鼠肝质膜上胰岛素受体的数量。当以5mg/kg的剂量口服给药时,它降低了由高脂饮食和链脲佐菌素诱导的糖尿病大鼠模型中的血浆葡萄糖和甘油三酯水平,但不降低总胆固醇水平,并增加了血浆胰岛素水平。
Glipizide was found to be mildly fetotoxic in rat reproductive studies at all dose levels (5 to 50 mg/kg). This fetotoxicity has been similarly noted with other sulfonylureas, such as tolbutamide and tolazamide. The effect is perinatal and believed to be directly related to the pharmacologic...
治疗剂量因人而异,一般为5-20 mg/日。初用时于早餐前服2.5-5mg,若剂量超过10mg/日,宜分2次服用,最大剂量一般不超过30mg/日。治疗中随时监测空腹血糖和餐后血糖以调整剂量。 禁忌证 胰岛素依赖型糖尿病,糖尿病酮症,酸中毒,孕妇,肝肾功能不全,肾上腺皮质功能不全。 不良反应 恶心,呕吐,腹泻,腹痛,头痛。个别...
When added to therapy with other antidiabetic agents, may initiate glipizide extended-release tablets at a dosage of 5 mg daily. May use lower initial dosages in patients at risk for hypoglycemia.May initiate fixed combination of 2.5 mg of glipizide and 250 mg of metformin hydrochloride once da...
Mylan said theGlipizide Extended-release Tablets, 5 mg and 10 mg is generic version of Pfizer's GLUCOTROL XL. Mylan introduces generic GLUCOTROL XL Tablets for patients with type 2 diabetes mellitus has received approval from the Food and Drug Administration for its abbreviated new drug applicatio...
格列吡嗪(29094-61-9,Glipizide)抑制原代小鼠胰腺β细胞中的ATP敏感性钾(KATP)通道(IC50=6.4 nM)。格列吡嗪诱导分离的大鼠胰腺组织释放胰岛素,EC50值为40nM。格列吡嗪(5 mg/kg/天,连续10天)的饮食给药增加了分离和纯化的小鼠肝质膜上胰岛素受体的数量。当以5mg/kg的剂量口服给药时,它降低了由高脂饮食和链脲...