Glioma can affect functioning of the brain and it can be fatal, depending on its location and severity of tumor Glioma is of different types: astrocytomas, brain stem gliomas, ependymomas, mixed gliomas (oligo-astrocytomas), oligodendrogliomas, and optic pathway gliomas Headache; seizures; ...
“the stromal content and composition varies depending on the numbers of myeloid and lymphoid cells, as well as their relative importance to tumor growth.” Pay attention to the word “relative importance”. It’s clever to make hypothesis considering that the significance and role of immune cells...
Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has been recently identified as a transcriptional target of parkin. Interestingly, somatic mutations on parkin have also been linked to glioma genesis. We examined the possibility ...
Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are ... Xie,Jingwu - 《Oncoimmunology》 被引量: 3发表: 2014年 加载更多研究点推荐 anti-angiogenic treatment 辅助...
NF2 tumor formation and growth can be prevented by merlin activation, which can prevent cyclin D1 expression and mTORC1 activation. Further studying the causes of these types of tumors will allow for better treatment options to be developed. 展开 ...
ecosystem. We propose that upon tumor growth, various factors such as low pH and hypoxia can trigger the acquisition of the core phenotype due to phenotypic changes in various unknown cell types in ecosystem, which is then imprinted as cell-intrinsic mechanisms. Importantly, this study identified ...
Among the immune cell types, macrophages, microglia, and neutrophils were mutually associated and enriched in low purity gliomas, while only macrophages and neutrophils served as robust indicators for poor prognosis. Conclusion: In summary, glioma purity and relevant non-tumor cells within a ...
The immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment. Plasmacytoid dendrit... R Wang,Zhang, Ju-Liang,B Wei,... - 《Tumour Biology the Journal of the International Society for Oncodevelopmental Biology & Medicine》 被...
(Ostrom et al., 2015). They represent a broad class of tumor subtypes that originate from several types ofglia cells: the nonneuronal cells within theCNSthat maintainhomeostasis. The main types ofgliomadescribed in the literature areastrocytomas,oligodendrogliomas,ependymomas, and mixedgliomassuch ...
Malignant glioma, a highly aggressive tumor, is one of the deadliest types of cancer associated with dismal outcome despite optimal chemotherapeutic regimens. One explanation for this is the failure of most chemotherapeutics to accumulate in the tumors, additionally causing serious side effects in periph...