Despite a deeper molecular understanding, human glioblastoma remains one of the most treatment refractory and fatal cancers. It is known that the presence of macrophages and microglia impact glioblastoma tumorigenesis and prevent durable response. Herein we identify the dual function cytokine IL-33 as a...
Anaplastic astrocytoma and oligoastrocytoma have a better prognosis compared with glioblastoma. Standard therapy consists of adjuvant radiotherapy up to 60 Gy after surgery. The value of concomitant and/or maintenance chemotherapy with TMZ has not been tested prospectively [V, D]. Long-term follow-up...
Glioblastoma multiforme (GBM) is the most aggressive form of glioma, accounting for 55% of all cases [1]. Despite improvements in treatment success rates, the prognosis of GBM remains poor, with a median survival time of just 14.6 months [2]. The diffuse and invasive nature of GBM limits ...
However, the relationship between Ki-67 LI and prognosis in glioblastoma remains controversial [12, 38, 39]. DWI is a non-invasive method to detect the diffusion movement of free water molecules in tissues. ADC values can be used to indirectly understand the tightness and microstructure changes ...
Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. Methods The in vitro antineoplastic effect and mechanism of action of ...
Davis, M. E. Glioblastoma: overview of disease and treatment.Clin. J. Oncol. Nurs.20, S2–S8 (2016). ArticlePubMedPubMed CentralGoogle Scholar Cheng, F. & Guo, D. Met in glioma: signaling pathways and targeted therapies.J. Exp. Clin. Cancer Res.38, 270 (2019). ...
GlioblastomaEarly diagnosis of glioma is of great value to improve prognosis. We focused on serum vimentin levels as a useful biomarker for preoperative diagnosis. The aim of this study was to determine whether serum vimentin levels in patients with glioma are significantly higher than those of ...
Lactate has emerged as a critical regulator within the tumor microenvironment, including glioma. However, the precise mechanisms underlying how lactate influences the communication between tumor cells and tumor-associated macrophages (TAMs), the most abu
is a common driver mutation in mesenchymal glioblastoma17. It will be important for future studies to determine whether gliomas driven byNtrkfusions also tend to fall into the mesenchymal subtype, which has a particularly poor prognosis. Although glioma patients are not routinely tested forNTRK1rearr...
Human glioma is a high-grade brain tumor with poor prognosis and, currently, the only two treatment options are FDA approved: temozolamide and bevacizumab (Dickinson, 2014). In an effort to address the lack of treatment options, the Comparative Brain Tumor Consortium has been established to ...