Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare the epigenetic and tran...
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. GBM patients who undergo the standard of care, including surgical resection, chemotherapy, and radiotherapy, have a median survival of approximately 15 months1. Due to the early infiltrative nature of the disease, a...
vision, or motor functions can all indicate the presence of a brain tumour. Many brain tumours are initially discovered following chronic headaches, and in some cases seizures are associated with cancers of the brain. Symptoms may also includevomiting, nausea, or numbness in any part of the body...
In the present review, we highlight the impact of each element within the SOC on the treatment timeline of GBM and the characteristics of recurrent tumors. Additionally, we provide a comprehensive overview of preclinical models integrating SOC. This approach aims to improve the identification of ...
Figure 1. Historical timeline of the emergence of medical devices as therapeutic modality for GBM. This review aims to provide a comprehensive overview of the clinical applications of current and emerging medical devices that directly deliver or augment therapy for GBM. Notably, we recognize that ...
The experimental set up used in this study was based on the timeline described previously [40]. In brief, the investigation period lasted 21 days and started with tumor cell inoculation on day 0. A total of 1 × 105 GL261 cells were stereotactically inoculated into the right striatum (2 ...