A retrospective survey of the last 3 months of life in patients carrying glioblastoma: Clinical treatments and profilesdoi:10.3892/mco.2017.1479Romain RivoirardAlexis VallardC BoutetNicolas MagniSpandidos Publications
Glioblastoma has three distinct histologic variants: giant cell glioblastoma, gliosarcoma, and epithelioid glioblastoma (seeWorkup/Histologic Findings).[3] Signs and symptoms The clinical history of a patient with GBM is usually short (< 3 months in > 50% of patients).[4]The most common presenti...
Glioblastoma(GBM) is the most prevalent form of primary malignant brain tumor in adults and remains almost invariably lethal owing to its aggressive and invasive nature. There have only been marginal improvements in its bleaksurvival rateof 12–15 months over the last four decades. The lack of ...
For each patient, participation was planned to last ~7.5 months: from inclusion to surgery was a maximum of 14 days, from surgery to first sonication (Cycle 1) was a minimum of 9 days to a maximum of 14 days to allow for surgery recovery. Patients were then treated until month 6, tumo...
The most widely used system today for classification of astrocytomas is part of the WHO classification of tumors of the CNS, which was last updated in 2007.1 Grade I is reserved for subependymal giant cell astrocytoma and pilocytic astrocytoma, which are the most benign in terms of histology;...
(CNVs) that correlate with the MES phenotype, not previously described. Hypermutation status was found to be a predictor of increased T-cell infiltration at recurrence. Moreover, increased T-cell infiltration at recurrence was prognostic. Last, we mapped intercellular paracrine and autocrine signals ...
The last decade has seen significant effort and progress made in the development of 3D organoid systems to model GBM (Fig.1A). Galli and colleagues were the first to adopt neurosphere culture conditions to generate GSC-rich ‘glioma-spheres’, a PDO model which maintained cell polarisation and ...
Despite the enormous progress in biotechnology and medicine field, life expectancy of glioblastoma (GB) patients has improved only slightly over the last 30 years. As a matter of fact, if untreated, GB’s median survival means is 3 months [3]. Interestingly, the standard management of GB has...
Surgical resection, adjuvant radiation and postoperative chemotherapy remain the primary treatment modalities, and although many efforts have been made toward increasing life expectancy in the last decade, the prognosis remains dismal. Mean survival is about 12 months from diagnosis7 and fewer than 5% ...
Glioblastoma multiforme is the most common and the most aggressive primary brain tumor. It is characterized by a high degree of hypoxia and also by a remarkable resistance to therapy because of its adaptation capabilities that include autophagy. This deg