in accordance with examples 1-4 with mutated forms of p53 being used. Specifically, p53 proteins mutated at codon 248 (Arg to Trp) or at codon 273 (Arg to His) were used. The angiogenic response obtained was identical to that obtained with the parental conditioned medium, in all cases. ...
68. A method of treating a brain tumor characterized by AR expression in at least a portion of the tumor cells in a subject in need thereof, comprising administering to the subject a therapeutic combination of at least one AR antagonist or inhibitor and at least one anti-cancer agent selected...
In support of previous studies, we found that an elevated vessel tortuosity, even in singular, extreme cases, has the potential of serving as a geometric biomarker for tumor vasculature61,85,88. Despite the disruptive effects of tumor growth on the local vasculature, the pathological vessel ...
Abstract Glioblastoma multiforme is the most common and the most aggressive primary brain tumor. It is characterized by a high degree of hypoxia and also by a remarkable resistance to therapy because of its adaptation capabilities that include autophagy. This degradation proc...
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Intracranial lesions in patients with KTWS are extremely rare, and are generally reported as single cases in the literature. We describe a rare case, where a patient with KTWS was found with a hemorrhagic grade IV astrocytoma. Although central nervous system abnormalities such as intracranial ...
1 The incidence of GB is low compared to that of other tumors, but there is no localized and surgically curable form of GB as there is in other cancers, so all cases are considered grade 4. The standard first-line treatment for GB was established in 2005 as maximal safe surger...
Glioblastoma (GBM) is a therapeutic challenge, associated with high mortality. More effective GBM therapeutic options are urgently needed. Hence, we screened a large multi-class drug panel comprising the NIH clinical collection (NCC) that includes 446 FD
EGFR phosphorylation and ERK phosphorylation are both ligand-dependent in all cases, with no evidence for constitutive activation of the mutated receptors. Representative blots are shown for three biologically independent experiments. See Supplementary Fig. 1 for gel source data. b, IL-3-dependent Ba...
In most cases, the average RMSD for both the protein and epitope was lower for the mutated peptide (Table 3). The effect size of this difference, quantified using Cohen’s d descriptor, ranged from medium to huge (see details in the Methods section). In all simulations, the RMSD reached...