Primary brain tumors are given a tumor grade based on how abnormal the tumor cells look when viewed under a microscope.25For cancers in general, the tumor grade provides some information on how quickly a tumor is likely to grow and spread to other tissues. Grade I tumor cells largely resembl...
Glial-origin brain tumors, including glioblastomas (GBM), have one of the worst prognoses due to their rapid and fatal progression. From an oncological point of view, advances in complete surgical resection fail to eliminate the entire tumor and the rema
and primary or metastatic. Benign tumors are not considered cancer, but malignant ones are. Primary tumors originate in the brain first. Metastatic tumors develop after a cancer somewhere else in the body spreads to the brain.
A glioma is a tumor of the glial cells in the brain and spinal cord. Gliomas can range from benign and slow-growing to the most aggressive and malignant brain tumors. Glioma types include astrocytoma, oligodendroglioma, ependymoma, and glioblastoma. Gliomas may be low-grade or high-grade based...
Brain tumors with transplantation of GSPT1-KO U87 cells also showed enhanced apoptosis compared to those with transplantation of WT and Rescued GSPT1-KO U87 cells. GSPT1 expression was confirmed in patients with glioblastoma. However, the clinical study using 87 glioblastoma samples showed that GSP...
In current clinical practice, therapeutic decisions are often made after molecular analysis [55,56] of only a single biopsy sample from the primary tumors, but not of metastasis that may reveal branched dissemination to brain [31]. For example, efficacies of ALK and EGFR inhibitors, used in pr...
A comprehensive review of the rationale and clinical experience. J. Neurooncol. 113, 163–174 (2013) Article CAS PubMed Google Scholar J. Basso, A. Miranda, S. Nunes, T. Cova, J. Sousa, C. Vitorino, A. Pais, Hydrogel-based drug delivery nanosystems for the treatment of brain tumors...
IMPORTANCE Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100 000 population or 17 000 new diagnoses per year. These tumors are typically associated with a dismal prognosis and poor quality of life.OBJECTIVE To review th...
Shankar, G. M., Balaj, L., Stott, S. L., Nahed, B. & Carter, B. S. Liquid biopsy for brain tumors.Expert Rev. Mol. Diagn. Nieder, C., Grosu, A. L., Astner, S. & Molls, M. Treatment of unresectable glioblastoma multiforme.Anticancer Res., 4605–4610 (2005). ...
Stem cell-based therapies for neurological disorders, including brain tumors, advance continuously toward clinical trials. Optimized cell delivery to the c... MATTHIAS REITZ,a MARIA DEMESTRE,a JAN SEDLACIK,... - 《Stem Cells Translational Medicine》 被引量: 82发表: 2012年 Evaluation of Microvascu...