10 (ICD-10) sudden death is non-violent and not otherwise explained, occurring less than 24 hours from the onset of symptoms.3 There are several studies across the world that give ideas about patterns and profiles of cases of sudden death in relation to different age groups.4'10 As ...
The combination of ICBs with chemotherapy, particularly TMZ, is one of the most studied combination therapies for GBM. The combination of chemotherapy and ICBs offers the advantage of enhancing the recognition and elimination of tumor cells (e.g., by increasing tumor antigenicity, inducing ICD and ...
Tumor associated macrophages (TAMs) and malignant cell undergoing immunogenic cell death (ICD) may serve as the source of producing IFN-γ in its tumor microenvironment (TME), which leads to downstream signaling activation [9, 10]. IFN-γ signaling activation has been proposed to induce ...
GB is a well-known “immunologically cold tumor” and its tumor microenvironment contains very few cytotoxic T lymphocytes. Under these circumstances, even if the PD-1/PD-L1 pathway is blocked, patients cannot mobilize enough effector T cells to kill their tumor cells. It is likely that other ...
Australian cancer incidence and mortality (ACIM) books, brain cancer for Australia (ICD10 C71). Mohri M, Nitta H, Yamashita J. Expression of multidrug resistance-associated protein (MRP) in human gliomas. J Neurooncol. 2000;49(2):105–15. Article CAS Google Scholar Sugiyama D, Kusuhara ...
Introduction Glioblastoma (GB) is the most aggressive primary brain tumor in adults accounting for >50% of the tumors of the brain. After surgery, radio- and chemotherapy, survival remains dismal and less than 15 months [1]. Three main properties of the tumor hampers its successful treatment:...
Glioblastoma is most commonly a primary brain tumor and the utmost malignant one, with a survival rate of approximately 12–18 months. Glioblastoma is highly heterogeneous, demonstrating that different types of cells from the same tumor can manifest dist
For survivors of childhood cancer, the cumulative incidence of SPTs arising within 30 years after initial tumor diagnoses ranges from 3 to 10% [3]. This is roughly 3–6 times higher than comparable rates in the general population. The most common SPTs encountered are breast cancer for female...
https://doi.org/10.3390/cells10020340 https://www.mdpi.com/journal/cells Cells 2021, 10, 340 2 of 21 1. Introduction Glioblastoma (GB) is one of the most aggressive cancers, and unfortunately, the most frequent among brain tumours. It is characterized by distinct histological ...
TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging interpretation may be challenging. We therefore