Astrocytomas are a type of brain cancer. Bothastrocytomasand glioblastomas start inbrain cellscalled astrocytes. These cells help give your brain the nutrients it needs. Glioblastomas used to be considered grade 4 astrocytomas, which meant that they were advanced, aggressive astrocytomas. Scientists...
Researchers at Cold Spring Harbor Laboratory (CSHL) say they have discovered that a protein known as BRD8 may represent a previously unknown vulnerability in the deadly brain cancer glioblastoma (GBM). The results of laboratory studies by Alea Mills, PhD, and colleagues demonstrated how BRD8...
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with marginal life expectancy. Based on the assumption that GBM cells gain functions not necessarily involved in the cancerous process, patient-derived glioblastoma cells (GCs) were screened to identify cellular processes amenable...
Currently, GBM has a life expectancy of 14 to 15 months post diagnosis. The molecular heterogeneity of GBM makes it difficult to treat. Our chemotherapy and immune therapies do not cross the blood-brain barrier, and the tumor has a propensity to mutate and become resistant to chemo...
- 《Cancer》 被引量: 0发表: 1997年 Identification of molecular subtypes of glioblastoma by gene expression profiling Oncogene is one of the world's leading cancer journals. It is published weekly and covers all aspects of the structure and function of Oncogenes. PS Mischel,R Shai,T Shi,.....
INTRODUCTION: Success in the treatment of young people with cancer, as measured conventionally by survival rates, is mitigated by late effects of therapy that impose a burden of morbidity and limit life expectancy. Among these adverse se... R Barr,T Nayiager,C Gordon,... - 《Bmj Open》 被...
Glioblastoma multiforme, a type of deadly brain cancer, originates most commonly from astrocytes found in the brain. Current multimodal treatments for glioblastoma minimally increase life expectancy, but significant advancements in prognosis have not been made in the past few decades. Here we investigate...
Cellular uptake of cobalamin in clinically-derived blood samples, normal and cancerous brain cells. The cellular uptake and sequestration of fluorescently labeled cobalamin by cancer cells and normal cells was studied by fluorescence flow cytometry and fl... Y Shi - The University of Utah. 被引量...
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults with peak incidence in patients older than 65 years. These patients are mostly underrepresented in clinical trials and often undertreated due to concomitant diseases. Recently, different therapeutic approaches for el...
Chemotherapy –In chemotherapy, doctors uses drugs to kill the cancer cells and stops the growth of tumor. Chemotherapy can be taken orally or via injections. In chemotherapy, drugs were used to kill the tumor cells damaging the brain tissues. The drugs used in the treatment help in reducing...