A new preparation of the sulphonylurea gliclazide has been developed incorporating the molecule in a hydrophilic matrix which ensures a progressive release of drug over a 24-hour period. The gliclazide modified release (MR) preparation produces effective plasma concentrations of gliclazide within the ...
Bilxona modified-release Actavis UK, United Kingdom Cadicon Pharmaceutical Laboratories, Thailand Chemmart Gliclazide Apotex, Australia Chitian Chen Ho, Taiwan Claformin [+ Metformin] Orchid, India Claz Franco-Indian, India Clazic SR United International Pharma, Vietnam ...
This difference in drug release rate in different acidic and alkaline media is due to rapid degradation of PLGA in acidic medium, where the equivalent ratio of lactic acid and glycolic acid were auto catalyzed over a period of time and increase in both concentrations may result in initial quick...
3.3.5. In Vitro Release of GCZ NS In USP type II equipment (LABINDIA, model no: DS 8000; Mumbai, India), a dissolution test of plain drug and NS of GCZ (equivalent amount of 40 mg) was performed. The samples were placed in a phosphate-buffered medium (pH 7.4; 900 mL). Through...