A new preparation of the sulphonylurea gliclazide has been developed incorporating the molecule in a hydrophilic matrix which ensures a progressive release of drug over a 24-hour period. The gliclazide modified release (MR) preparation produces effective plasma concentrations of gliclazide within the ...
Drug release was not complete at the end of the dissolution test from microparticles incorporated in Jelly 1, 2, and 3 at CL25. When incorporating microparticles at CL20 into Jelly 1, drug release profile was equivalent to Diamicron SR tablets (f2 = 59.7, p = 0.930). Monitoring the pH ...
Bilxona modified-release Actavis UK, United Kingdom Cadicon Pharmaceutical Laboratories, Thailand Chemmart Gliclazide Apotex, Australia Chitian Chen Ho, Taiwan Claformin [+ Metformin] Orchid, India Claz Franco-Indian, India Clazic SR United International Pharma, Vietnam ...
In a real-world UK Clinical Practice Research Datalink (CPRD) database study of people with T2D initiated on second-line GLD therapy with either gliclazide modified-release (MR) or sitagliptin, gliclazide MR-treated participants were more likely to achieve an HbA1c of < 7% (< 53.0 mol/...
This difference in drug release rate in different acidic and alkaline media is due to rapid degradation of PLGA in acidic medium, where the equivalent ratio of lactic acid and glycolic acid were auto catalyzed over a period of time and increase in both concentrations may result in initial quick...