Bilxona modified-release Actavis UK, United Kingdom Cadicon Pharmaceutical Laboratories, Thailand Chemmart Gliclazide Apotex, Australia Chitian Chen Ho, Taiwan Claformin [+ Metformin] Orchid, India Claz Franco-Indian, India Clazic SR United International Pharma, Vietnam ...
This difference in drug release rate in different acidic and alkaline media is due to rapid degradation of PLGA in acidic medium, where the equivalent ratio of lactic acid and glycolic acid were auto catalyzed over a period of time and increase in both concentrations may result in initial quick...
Figure 3. In vitro gliclazide release and response surface methodology results of gliclazide release over 8 h (DR 8 h). Cumulative gliclazide release from different beads compared to marketed gliclazide modified release formula (Diamicron® 30 mg MR) (A). Mathematical release kinetic models (B)...
gliclazide nanofibers formulation, developed with PVA/PLGA, successfully achieved a modified drug release to meet the typical physiological needs of T2DM, such as a faster drug release at the time of meals followed by prolonged drug release profile over an extended period to maintain constant plasma...