Gliclazide is an oral antidiabetic drug used to treat type 2 diabetes mellitus. It belongs to the sulfonylurea class of drugs and works by stimulating the pancreas to release insulin, thereby lowering blood glucose levels. Gliclazide is also known to have beneficial effects on the microcirculation,...
Administration of gliclazide to type 2 diabetic patients could form part of the strategy for the prevention and management of diabetic cardiovascular diseases Drug interactions Potentially hazardous interactions with other drugs Analgesics: effects enhanced by NSAIDs. Antibacterials: effects enhanced by ...
Management of Antidiabetic Medications in Overdose The drugs used to treat diabetes mellitus are diverse and involve several classes. However, these drugs can be roughly separated into hypoglycaemic agents,... HA Spiller - 《Drug Safety An International Journal of Medical Toxicology & Drug Experience...
because of the increased risk of hypoglycaemia. They should be avoided where possible in severe renal impairment. Hypoglycaemia: Consider the time-action profile of the drug and its effect on the patient’s lifestyle, eating pattern, occupation, age and hypo awareness. Ensure the patient understand...
The drug-class of SGLT2 inhibitors improves outcomes at both ends of this so called cardiorenal axis. We assessed the effects of SGLT2 inhibition and sulfonylurea treatment on systemic hemodynamic function and investigated whether SGLT2 inhibitor-induced changes in systemic hemodynamics correlate wi...
Drug delivery and therapeutic challenges of gliclazide, a BCS class II drug used in type 2 diabetes mellitus (T2DM) can be overcome by exploring smarter carriers of second-generation nanocrystals (SGNCs). A combined method of emulsion diffusion, high-pressure homogenization and solvent evaporation me...
Metformin is not bound to plasma proteins, 40-60% of the dose is recovered as unchanged drug in urine with a further 30% recovered as unchanged drug in faeces. INDICATIONS Non-insulin dependent diabetes mellitus; diabetes with or without obesity in adults. ...
The drug-class of SGLT2 inhibitors improves outcomes at both ends of this so called cardiorenal axis. We assessed the effects of SGLT2 inhibition and sulfonylurea treatment on systemic hemodynamic function and investigated whether SGLT2 inhibitor-induced changes in systemic hemodynamics correlate with ...
The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So an attempt was made to enhance the solubility of gliclazide by solid dispersion technique. In this sodium starch glycolate, crospovidone were mixed with the...
Gliclazide (GLZ) BCS class II drug, is an oral antihyperglycemic agent used for the treatment of non- insulin-dependent diabetes mellitus However, low aqueous solubility and poor dissolution of this molecule, delays its rate of absorption and finally the onset of action. Solid dispersion has been...