It is not safe to use this drug while pregnant; breastfeeding studies are unavailable. Use in children under the age of 18 is infrequent; consultation with a specialist (such as a pediatriconcologist) is recommended. Many medical conditions and drugs affect the levels of Gleevec in patients, s...
【药物名称】Imatinib mesylate, GGP-57148B, STI-571, CGP-57148(free base), Gleevec, Glivec 化学结构式(Chemical Structure): 参考文献No. 21932 标题: Pyrimidine derivs. and process for their preparation 作者: Zimmermann, J. (Novartis AG) 来源: EP 0564409; JP 1994087834; US 5521184 合成路线图解...
et al. NMR characterization of kinase p38 dynamics in free and ligand-bound forms. Angew. Chem. Int. Edn. Engl. 45, 993–997 (2006). Article CAS Google Scholar Shan, Y. et al. A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc. Natl. Acad. Sci....
Seven calibration standards ranging from 50 to 7500 ng/ml (50( 150) 450( 2000) 3000, 4500 and 7500 ng/ml)were pre-pared by diluting the stock solution in 200,l drug free cell suspensions,and stored in Eppendorf tubes at−20◦C.Quality controls were prepared in nominal concentrations ...