Additional titration may be needed to minimize the risk of hypoglycemia or hyperglycemia (e.g., with changes in physical activity, diet or timing of food intake, during acute illness; or when used with other medications.Use: As an adjunct to diet and exercise to improve glycemic control in ...
When insulin glargine is used in fixed combination with lixisenatide or other drugs, consider the cautions, precautions, contraindications, and interactions associated with the concomitant agent(s) in addition to those associated with insulin glargine....
When your body needs insulin, there are ways to help replace or supplement it. One of them is long-acting basal insulin.1 How can insulin help? When first diagnosed, many people with type 2 diabetes can keep their blood glucose at a healthy level with a combination of meal planning, phys...
Thiazolidinediones are peroxisome proliferator-activated receptor (PPAR)-gamma agonists and can cause dose-related fluid retention, particularly when used in combination with insulin; fluid retention may lead to or exacerbateheart failure; monitor for signs and symptoms of heart failure, treat accordingly,...
when these symptoms most likely occur. In the early stages, a strategy of starting exenatide with a lower thanmaintenance dose, slowly increasing to the desired steady state, was found to reduce problems with gastrointestinal adverse events. Since then, recommendations have been developed for such ...
When there isn’t enough insulin or cells stop responding to insulin, too much glucose stays in the bloodstream. Over time, that can cause serious health problems, such as heart disease, vision loss, and kidney disease3. Insulin Glargine Insulin glargine is a long-acting insulin analog, ...
Toujeo SoloStar and ToujeoMax SoloStarare single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in theInstruction Leafletthat comes with your Toujeo...
The maximum glucose lowering effect of a dose of TOUJEO may take five days to fully manifest and the first TOUJEO dose may be insufficient to cover metabolic needs in the first 24 hours of use [seeCLINICAL PHARMACOLOGY]. To minimize risks associated with insufficient insulinization when initiating...
Using rubbing alcohol to clean the skin where you are going to inject. Alcohol can sometimes sting if it’s not completely dry when you inject, so wait a few seconds for it to evaporate or pat the area dry with a sterile cotton ball. Pinch a Fold of Skin: Pinch the skin and hold...
In March 2021, when Lannett first announcedintentionsto conduct a pivotal trial of its insulin glargine candidate, there were no biosimilar insulins on the US market. That changed in July 2021 when Semglee, a Biocon Biologics/Viatris product, received FDA approval as the first insulin glargine bi...