Intervention Conversion from insulin glargine to NPH insulin. Main outcome measures HbA1c, 30-day average blood glucose, number of suspected and confirmed hypoglycemic episodes, total insulin dose, and Morisky Medication Adherence Scale (MMAS) scores. Results Patients in both control and intervention ...
1.A polypeptide hormone that is secreted by the beta cells of the islets of Langerhans in the pancreas and functions in the regulation of carbohydrate and fat metabolism, especially the conversion of glucose to glycogen, which lowers the blood glucose level. It consists of two linked polypeptide...
Conversion from bedtime NPH to morning glargine appears efficacious with no increase in frequency of hypoglycemia. 展开 关键词: Glargine Intensive insulin therapy Type 2 diabetes Basal-prandial insulin therapy DOI: 10.1016/j.diabres.2005.12.009 被引量: 84 ...
2) provide additional explanatory evidence in support of the definitive findings in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) study in which exposure to insulin glargine for a median duration of 6.2 years did not
human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day), maternal toxicity due to dose-dependent hypoglycemia, including some deaths, was observed. Consequently, a reduction of the rearing rate occurred in the high-dose group only. Similar effects were observed with NPH insulin....
Study design Trial EFC11202 The primary objective was to determine the efficacy of insulin glargine dosed in the morning compared to NPH insulin on the rate of “all hypoglycaemia”. Secondary objectives were to assess the effects of insulin glargine versus NPH on HbA1c levels; safety and ...
Conclusions Conversion to IDet from an IGla regimen improved life expectancy and was a cost-saving treatment approach in a Chinese setting.LiYangandTorstenChristensenandFengyuSunandJinghuaSDOSValue in HealthCost-Effectiveness of Switching Patients with Type 2 Diabetes from Insulin Glargine to Insulin ...