The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and
Using fate-mapping to distinguish cells arising from primitive versus definitive hematopoiesis initially suggested that adult MF populations in lung, dermis, and spleen arise predominantly from definitive hematopoiesis with negligible contribution from YS MFs (Ginhoux et al., 2010). However, a new ...
Many patients with temporal lobe epilepsy display structural changes in the seizure initiating zone, which includes the hippocampus. Structural changes in the hippocampus include granule cell axon (mossy fiber) sprouting. The role of mossy fiber sproutin
Amidst the major transformation of the global system after the Cold War, the study of international relations has maintained a predominantly top-down orientation. This apex-centred focus comes out most clearly in the important debates co... Cooper,Andrew F - Palgrave Macmillan UK 被引量: 60发表...
Importantly, polyploid hepatocytes that undergo multiple rounds of cell division become predominantly mononucleated and are resistant to ploidy reduction. Our results suggest that ploidy reduction is an early step in the initiation of carcinogenesis from polyploid hepatocytes....
These data demonstrate that committed nephron progenitors can give rise to Wilms tumors and that committed stromal progenitors are less tumorigenic, suggesting that human Wilms tumors that display a predominantly stromal histology arise from mesenchyme before commitment to a stromal lineage....
Mutations in the human GCS1 gene give rise to the congenital disorder of glycosylation termed CDG IIb. Lec23 mutant cells have been shown to alter lectin binding and to synthesize predominantly oligomannosyl N-glycans on endogenous glycoproteins. A single point mutation (TCC to TTC; Ser to Phe...
Although most of the resulting proteins may have no significant biological function, they can be meaningful for the immune system, which is sensitive to extremely low levels of Ag. We have tested this possibility by investigating the ability of CD8+ T cells (TCD8+) to respond to an epitope ...
ALAT is predominantly present in the cytosol of hepatocytes and ASAT is predominantly present in the mitochondria. When hepatocytes sustain damage to their membranes ALAT is released from the cytosol, whereas when hepatocytes sustain more severe damage ASAT is released from the mitochondria [6–8]. ...
"The currently discussed rise in individualism is not something recent but has been going on for centuries as we moved from a predominantly rural,low-tech society to a predominantly urban,high-tech society."Professor Greenfield,whose work is published in the journal Psychological Science,used Google...