Incidental diagnosis of a spindle cell type gastrointestinal stromal tumor in a dog with ethylene glycol intoxication Priscila B S Serpa , Andrea P Santos Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West ...
the spindle cell type, which makes up approximately 70% of gists, is composed of fascicles and whorls of ovoid cells with eosinophilic, fibrillar cytoplasm. some show prominent paranuclear vacuolization, a feature shared with smooth muscle tumors. nuclear palisading and stromal lymphocytes, features...
Morphologically GISTs can be classified into spindle cell type (70%), epithelioid type (20%), and mixed type (10%) [6], [7]. Grossly, GISTs are submucosal lesions that appear to arise from the muscularis propria of the bowel wall. Intramural in origin, they often project exophytic extra...
Histologically this was a completely excised spindle cell type GIST, with eleven mitoses per fifty high power fields (high risk group). Download: Download high-res image (236KB) Download: Download full-size image Image 5. The excised specimen. Postoperatively, his recovery was slightly delayed...
Gastrointestinal stromal tumors are currently defined as c-kit (CD117)-positive spindle cell (or, less commonly, epithelioid cell or both) gastrointestinal tract mesenchymal tumors [1, 3]. The most important markers for defining GISTs are CD117 (c-kit protein) and CD 34 (hematopoietic cell ...
Histology showed a well-demarcated, lobulated bland spindle cell lesion. The tumour is composed of cells with mainly blunt ended nuclei. There is strong positive staining to CD117 and DOG-1. There is focal positive staining to Desmin and SMA. The tumour is negative for S100 AND but Pan...
A 50﹜ear﹐ld patient presented with a 5 cm large gastric tumor with a multinodular/plexiform growth pattern, mixed epithelioid and spindle cell morphology and focal pronounced nuclear atypia with hyperchromasia and high mitotic activity. Immunohistochemically, CD117 and DOGwere positive. SDHB and ...
Postoperative histopathology and immunohistochemistry revealed a gastrointestinal stromal tumor GIST of the spindle cell type, showing a CD-117, CD-34, SMA expression with possible starting point in the small intestine.CYBUKA, BARTOSZGOLASKI, MACIEJ...
Most of the GISTs driven by a KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutation. Histologically, GISTs look like spindle cell tumors most of the time, but they can be epitheoid or mixed type. Clinically, patients with small GISTs remain asymptomatic. In another case, ...
sporadic GIST which was documented with a 75 % mitotic rate is <5/50 HPF[11]. GISTs histologically classified intospindle cell, epithelioid, and mixed type, and the commonest cell morphology in NF1-associated GISTs is spindle cell type[12]. Our finding was sheets of an oval to spindle pl...