Incidental diagnosis of a spindle cell type gastrointestinal stromal tumor in a dog with ethylene glycol intoxication Priscila B S Serpa , Andrea P Santos Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West ...
the spindle cell type, which makes up approximately 70% of gists, is composed of fascicles and whorls of ovoid cells with eosinophilic, fibrillar cytoplasm. some show prominent paranuclear vacuolization, a feature shared with smooth muscle tumors. nuclear palisading and stromal lymphocytes, features...
Morphologically GISTs can be classified into spindle cell type (70%), epithelioid type (20%), and mixed type (10%) [6], [7]. Grossly, GISTs are submucosal lesions that appear to arise from the muscularis propria of the bowel wall. Intramural in origin, they often project exophytic extra...
Gastrointestinal stromal tumors are currently defined as c-kit (CD117)-positive spindle cell (or, less commonly, epithelioid cell or both) gastrointestinal tract mesenchymal tumors [1, 3]. The most important markers for defining GISTs are CD117 (c-kit protein) and CD 34 (hematopoietic cell ...
sporadic GIST which was documented with a 75 % mitotic rate is <5/50 HPF[11]. GISTs histologically classified intospindle cell, epithelioid, and mixed type, and the commonest cell morphology in NF1-associated GISTs is spindle cell type[12]. Our finding was sheets of an oval to spindle pl...
Histology showed a well-demarcated, lobulated bland spindle cell lesion. The tumour is composed of cells with mainly blunt ended nuclei. There is strong positive staining to CD117 and DOG-1. There is focal positive staining to Desmin and SMA. The tumour is negative for S100 AND but Pan...
It was considered to originate from gastrointestinal submucous (SM) and muscular propria (MP) lamina, which is constructed by spindle cell and epithelial cell. GIST is classified into four phenotypes according to differentiation and immunohistochemistry, namely muscular type, neural type, mixed type ...
Following surgery (7-cm-mass completely resected from ileocecal-junction with negative-margin) (histopathology T4-N0-M0-stage-3B CD-117-positive DOG-1-positive ileal GIST pleomorphic-spindle-cell hyperchromatic-nuclei >5/50-hpf high mitotic-count. arthralgia-myopathy-swelling improved dramatically ...
GIST are defined by the pathologist with different criteria : 1) clinical criteria: these tumors are developed from the intestinal tract, occasionally from the mesentery; 2) histological criteria: the tumoral proliferation is composed of spindle cells (70%), less frequently of epithelioid cells (...
The mitotic count was 20 mitoses per 50 HPF (range, 7–32 cm); spindle cell type was present in four cases, and one case showed an epithelioid phenotype. All cases were classified as high risk and expressed c-KIT. Moreover all tumors progressed, and two patients died from the disease....