the spindle cell type, which makes up approximately 70% of gists, is composed of fascicles and whorls of ovoid cells with eosinophilic, fibrillar cytoplasm. some show prominent paranuclear vacuolization, a feat
Morphologically GISTs can be classified into spindle cell type (70%), epithelioid type (20%), and mixed type (10%) [6], [7]. Grossly, GISTs are submucosal lesions that appear to arise from the muscularis propria of the bowel wall. Intramural in origin, they often project exophytic extra...
Incidental diagnosis of a spindle cell type gastrointestinal stromal tumor in a dog with ethylene glycol intoxication Priscila B S Serpa , Andrea P Santos Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West ...
Histological analysis of the resected tis- sue revealed a low-grade, spindle-cell type GIST with resection margins free of the tumor (Fig. 1A, B). The pathological grade classification was pT2N0, and the histologic grade was G1 with a mitotic rate of 1/5 mm2. ...
GISTs histologically classified into spindle cell, epithelioid, and mixed type, and the commonest cell morphology in NF1-associated GISTs is spindle cell type [12]. Our finding was sheets of an oval to spindle pleomorphic cells. Definitive diagnosis of GIST is done by Immunohistochemistry. ...
In particular, SDHBIHC-/SDHAIHC- GIST include a subgroup of young adult women patients with a well defined clinical and bio- logical profile, generally characterized by the gastric primary tumour localization, a predominantly mixed epithelioid and spindle cell morphology, diffuse IHC positivity for ...
There was no significant correlation between the histologic subtype (spindle cell vs. mixed type) and tumor recurrence (P = 0.3618). Immunohistochemically, all tumors expressed CD117, four tumors PDGFRA, ten tumors CD34, eight tumors smooth-muscle actin, one tumor desmin, and S-100 was ...
Gastrointestinal stromal tumors are currently defined as c-kit (CD117)-positive spindle cell (or, less commonly, epithelioid cell or both) gastrointestinal tract mesenchymal tumors [1, 3]. The most important markers for defining GISTs are CD117 (c-kit protein) and CD 34 (hematopoietic cell ...
Histologically, there are spindle cell type as major and epithelioid type as minor. Several immunophenotypes exist, but major combination of immunoreaction is KIT+/CD34+/伪CSMA-/S100-, making 91% for total number of GISTs in the stomach. GIST with positive immunmoreaction to smooth muscle ...
The mitotic count was 20 mitoses per 50 HPF (range, 7–32 cm); spindle cell type was present in four cases, and one case showed an epithelioid phenotype. All cases were classified as high risk and expressed c-KIT. Moreover all tumors progressed, and two patients died from the disease....